| Objective:Through a randomized controlled study, to observe the cancer patients’ clinical symptoms and quality of life after Oxaliplatin-containing chemotherapy, as well as the preventive and curative effect of comprehensive therapy of traditional Chinese medicine, and then assess its efficacy on peripheral neurotoxicity. Methods:In accordance with the random principle, the study randomly divided the cases that met the inclusion criteria into control group and treatment group. The control group received Oxaliplatin chemotherapy without any other treatments, and all the enrolled patients were ordered to avoid cold drinks and exposure to cold things during chemotherapy; the treatment group adopted the same chemotherapy regimen, but received the comprehensive therapy of taking modified Astragalus and Cinnamon Twig Five Ingredients Decoction and Angelica Cold-Extremities Decoction orally two days before the application of oxaliplatin:Radix Astragali preparata30g, Cassia Twig10g, Angelica sinensis10g, Herba Asari10g, dry Radix Ginseng lOg, Lycopodium clavatum30g, Clematis chinensis30g, Radix Paeoniae Alba30g, ginger10g,5Fructus jujubae, Flos carthami6g and scorpion10g. After being decocted with750ml water,450ml of decoction would be obtained, which was taken150ml once, three times daily for7days. The blood-activating and stasis resolving recipe (Astragalus Gui Zhi Wu Wu the Tonga Dangguisini Soup addition and subtraction Jianqu of liquid dregs+Phryma leptostachya50g, Chuanwu10g, Dried toad skin10g) was decocted with1300ml water to obtain1000ml of decoction, soaked for30minutes every time and three times a day. The treatment time of two groups above was5cycles. Grading standard of peripheral neurotoxicity by NCI (National Cancer Institute) was used to make an evaluation of the efficacy. Class0:no; Grade Ⅰ: the weakened tendon reflexes or paresthesia present without impacts on functions; Grade Ⅱ:the weakened tendon reflexes or paresthesia present with some impacts on function and no affect on daily activities; Grade Ⅲ:tendon reflexes is lost, and sensation is lost or paresthesia has impacts on daily activities; Grade IV:permanent loss of sensation or/and dysfunction occurs. Patient’s condition should be recorded48h after chemotherapy. A week after chemotherapy, the grade of peripheral neurotoxicity decreasing to Grade0meant it’s cured, decreasing by1grade meant effective, decreasing by above2grades meant excellent and no change meant invalid. Data of the two groups were compared. Results:The improvement of symptoms after Oxaliplatin-based chemotherapy, quality of life and toxicity grading of the traditional Chinese medicine treatment group were significantly better than those of the control group (P<0.05), especially in numbness and hypoesthesia, relieving clinical symptoms, enhancing patients’ confidence in chemotherapy and improving chemotherapy compliance. Conclusion:Comprehensive therapy of traditional Chinese medicine for Oxaliplatin-induced peripheral neurotoxicity can relieve patients’clinical symptoms effectively, improve patients’ quality of life significantly and enhance patients’ confidence in chemotherapy as well as their compliance with chemotherapy. |
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