Explore The Value Of Plasma CGA Concentration In Evaluating The Severity Of Critical Ill Patients

Objective: To explore the relationship between the serum CGA level atadmission and illness severity scores, and prognosis in critically ill patients.Methods:139consecutive patients admitted to intensive care unit wererecruited and divided into three groups: no SIRS, SIRS and sepsisgroup.The concentrations of serum CGA and PCT at admission weremeasured. APACHE Ⅱ was calculated as well as SAPS Ⅱ and SOFA.Results: Serum CGA concentrations in SIRS and sepsis patients weresignificantly increased comparing to health controls and no SIRS patients(P<0.05). CGAconcentration positively correlated with PCT,APACHEⅡ,SAPS Ⅱ and SOFA.ROC analysis indicated that CGA,PCT,APACHEⅡ,SAPS Ⅱ and SOFA were all good at predicting the mortality of ICUpatients (AUC were respectively0.843,0.755,0.857,0.863and0.891).Kaplan-Meier analysis showed that the mortality of CGA increasedgroup (with CGA concentration193.65μg/L as the cutoff value) wassignificantly higher than control group.Conclusion: Serum CGA level at admission was positively correlated with severity in critically ill patients. Patients with serum CGAconcentration higher than193.65μg/L have a significantly higher mortalitythan control group. CGA is an independent indictor to evaluate the risk ofdeath for ICU patients.