| Objective： Cervical cancer is the most common gynecologicalmalignant tumor, with squamous carcinoma the most common type. Thetreatment of locally advanced cervical cancer remains controversial. Twometa analysis indicated that, neoadjuvant chemotherapy(NACT) andradical surgery is more effective compared with radiotherapy, the overallfive-year survival increases by about14%，but this only limited to theresponders. Effective neoadjuvant chemotherapy can reduce the localtumor size,and make the following radical surgery become feasible anddecrease the need of postoperative adjuvant radiotherapy orchemoradiotherapy. MRI is recognized as an objective means to assesschemotherapy response. However, it could not always reflect chemotherapyresponse due to various reasons, and as a result we need to explore areliable parameter to judge the chemotherapeutic efficiency duringdecision-making.Methods: Data from709patients with uterine cervical cancer was collected.331cases of cervical squamous cell carcinoma was selectedaccording to the strict inclusion criteria. We retrospectively analyzed thecorrelation between SCC–ag and chemotherapy response.Results：There was no significantly statistical difference in age,menstruation,stage,lymph node state,pathological grade and others betweenresponders and non-responders,indicating that it was irrelevant with theabove factors. The change of SCC-ag level is an independent factor forjudging the responsiveness of chemotherapy. After the first chemotherapythe SCC-ag level decrease by50.4%got the best diagnostic value,and thesensitivity and specificity was65.2%、76.1%respectively.Conclusions：Our study suggests that serum SCC ag is the effectiveand reliable indicator to access response to new-adjuvant chemotherapy incervical squamous cell carcinoma. |
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