The Predictive Value Of SCC-Ag Combined With PLR For Neoadjuvant Chemotherapy Sensitivity Of Cervical Squamous Cell Carcinoma

Objective: To explore the predictive value of serum squamous cell carcinoma antigen(SCC-Ag)combined with platelet to lymphocyte ratio(PLR)on the sensitivity or efficacy of neoadjuvant chemotherapy for cervical squamous cell carcinoma,so as to provide certain reference for clinical application of neoadjuvant chemotherapy.Method:The clinical data of 76 patients with?B2-?B cervical squamous cell carcinoma treated in central hospital of wuhan Obstetrics and Gynecology Department from January 2016 to June 2019 were retrospectively analyzed.According to the effect of neoadjuvant chemotherapy,they were divided into chemotherapy effective group(53 cases)and ineffective group(23 cases).The changes of serum SCC-Ag level and PLR value before and after chemotherapy were compared between the two groups.ROC curve was drawn to evaluate the predictive value of SCC-Ag level and PLR value for neoadjuvant chemotherapy of cervical squamous cell carcinoma and to determine the optimal critical point.To analyze the relationship between serum SCC-Ag level,PLR value and various clinical factors.Univariate and multifactorial analysis were used to analyze the relationship between serum SCC-Ag level,PLR value and neoadjuvant chemotherapy efficacy,and to determine the independent factors for predicting neoadjuvant chemotherapy sensitivity.Results:1.The effective rate of neoadjuvant chemotherapy was 69.7% in 76 patients with cervical squamous cell carcinoma.2.the serum SCC-Ag level in the effective group was significantly higher than that in the ineffective group before chemotherapy(P< 0.001),while the SCC-Ag level in the effective group was lower than that in the ineffective group after chemotherapy,with no significant difference(p > 0.05).SCC-Ag level of the effective group was significantly higher than that of the ineffective group after the initial chemotherapy,and the difference was statistically significant(P<0.001).3.The PLR value of the effective group before chemotherapy was significantly lower than that of the ineffective group(P<0.05).Compared PLR values before and after neoadjuvant chemotherapy,PLR value of the effective group before chemotherapy were slightly higher than those after chemotherapy,and the difference was not statistically significant(P>0.05).4.the AUC for predicting the chemotherapyeffect of cervical squamous cell carcinoma patients by combining the two indexes is0.819,which is slightly higher than that of SCC-Ag alone(AUC=0.800)and PLR alone(AUC=0.743)before chemotherapy,but the difference is not statistically significant(P>0.05).5.SCC-Ag level and PLR value before chemotherapy are independent predictors of neoadjuvant chemotherapy efficacy in cervical squamous cell carcinoma patients.Conclusion: 1.The change of serum SCC-Ag level after primary chemotherapy is closely related to the curative effect of neoadjuvant chemotherapy.2.Serum SCC-Ag level and PLR value before chemotherapy have certain predictive value for neoadjuvant chemotherapy sensitivity of cervical squamous cell carcinoma.3.The combined prediction has a tendency to be higher than the prediction of SCC-Ag level and PLR value before chemotherapy,but the difference is not statistically significant.