Posterior Injured Vertebra Transpedicular Fixation In Management Of Thoracolumbar Fractures

Cervical intraepithelial neoplasia (CIN) is a group of closely related precancerouslesions and invasive cervical cancer, reflecting the continuous process of occurrence anddevelopment of cervical cancer.It was first introduced by Richart in1967,1988byBathasda (TBS) system into collectively.According to the epithelial layer and cellpathology occupies,CIN lesions can be divided into CIN1, CIN2and CIN3.In recentyears, along with the development and popularization of "the three ladder" diagnosticsteps and medical technology, more and more CIN patients get early diagnosis andtreatment, and the treatment of CIN is more and more simple, quick, the effect is also tobe sure.Although CIN treatment method diversification, but whatever the means oftreatment, through the display of CIN patients, some patients still relapse. AmericanSociety For Colposcopy And Cervical Pathology (ASCCP) recommendation: to thesatisfaction of the colposcopy CIN2,3patients, cervical conization using fertilitypreservation, and the treatment failure rate is about1%to25%.After CIN treatmentfailures lead to recurrence of CIN, and is likely to progress to invasive cancer, therefore,distinguish the high risk of recurrence in patients with CIN after treatment, earlyprevention and control the recurrence of CIN, has an important significance forrecurrence and progression of disease control.Through the retrospective analysis methodin this study, analyze the relationship between clinical and pathological data of CINpatients with recurrece after surgical treatment.Objective: Analysis the correlation between recurrence and patients with clinicaland pathological factors of CIN patients, To discuss the risk factors of postoperativerecurrence of CIN patients, and then provide the clinical basis for the prevention andcontrol of CIN in patients with recurrence after operation.Methods: Collection A collection of clinical and pathological data of275patientswith cervical intraepithelial neoplasia in the tumor hospital of Liaoning Province from 2007, January to2010December.Using SPSS16.0Pearson χ2test, Fisher ’s test andLogistic regression analysis retrospective analysis of the relationship between patientswith CIN recurrence after operation and the patient’s age, gravidity, parity, number ofsexual partners, family history of cancer, smoking, drinking, menopause, mode ofoperation, resection margin involvement, gland body involvement, organization types,preoperative Pathology grade, preoperative and postoperative6months HPV.Results:In the collected275patients,9patients had recurrence, the recurrencerate was3.72%(9/275), including2cases of postoperative recurrence within6months-1years, accounting for22.2%(2/9);2cases of recurrence within1-2years, accountingfor22.2%(2/9);5patients above2years recurrence after operation, accounted for55.6%(5/9).Univariate analysis showed that patients with parity (≥2), the number ofsexual partners (≥2), menopause and HPV positive after6months of operation aresignificantly related to patients with CIN recurrence,(χ2=6.641;4.443;9.275;16.255),the differences were statistically significant (P=0.05);The preoperative Pathologygrade may be risk factors for relapse after CIN(χ2=14.298, P=0.067);And the patient’s age, pregnant times, family history ofcancer, smoking, drinking, operation mode, margin status, glandular involvement,histological type and preoperative HPV positive are not correlation with relapsed CINpatients,(χ2=0.469;1.458;1.316;0.203;0.462;2.287;0.172;--;2.273;14.298;1.402), there was no statistically significant difference (P>0.05);Multivariate Logisticregression analysis showed that the number of sexual partners of patients (≥2),menopause, HPV positive after6months of operation were independent risk factors ofrecurrence in patients with CIN (OR=8.562;21.358;27.691), the difference wasstatistically significant (P=0.05).(P<0.05).Conclusion: Parity(≥2), the number of sexual partners (≥2), menopause andHPV positive after6months of operation are significantly related to patients with CINrecurrence,The preoperative Pathology grade may be risk factors for relapse in patientswith CIN, and the number of sexual partners of patients (≥2), menopause, HPV positiveafter6months of operation were independent risk factors of recurrence in patients withCIN.There is a certain significance on the prediction of CIN patients with postoperativerecurrence.