The Relationship Between Parity And Glucose Metabolism In Femal

Objective:To analyze the different reproductive experiences and glucose metabolism of middle-aged and elderly women in Lanzhou,and to explore the relationship between women parity and different glucose metabolic status.Method:This epidemiological study adopting cluster random sampling method and using the "REACTION research" baseline data of Gansu province.This study selecting female residents aged 45-70 years old who met the standard in Lanzhou community.The related questionnaire,physical examination and laboratory examination were collected.According to the research object of the parity divided into P1(0-1),P2(2),P3(3),P4(over 4 times)a total of four groups,statisticed and analysised the different reproductive experiences and glucose metabolism status,and then discussed the correlation between the number of parity and different glucose metabolism status.Results:(1)There were 6246 subjects in the study,the number of P1 and P2,were P3 and P4 respectively accounted for 54.9%,24.2%,12.6%,7.7%.(2)Normal glucose tolerance(NGT),impaired glucose regulation(IGR),and diabetes(DM)accounted for 50.5%,28.5%,and 21%,respectively,of which 49.5% of the subjects had abnormal glucose metabolism.(3)Sperman correlation analysis showed that age,waist circumference,BMI,hypertension,dyslipidemia,age of menarche,number of menstruation,and positive correlation with FPG and 2hPG;menopause age is positively related to FPG and not related to 2hPG;the history of fetal macrosomia is negatively related to FPG and 2hPG.(4)Logistic regression analysis showed that in the case of unadjusted miscellaneous factors,the number of menstruation is an independent risk factor for diabetes.On the basis of these factors,the correlation of age,menarche age,menopause age,fetal history and other fertility factors has been slightly weakened,but there is still a statistical difference(P<0.05);after further adjustment of the marital status,living conditions,education,hypertension,blood lipid abnormality,BMI and other factors,the risk of diabetes in P2,P3 and P4 increased gradually compared with the parity of P1,and the difference was statistically significant(P<0.05).Conclusion:1.female parity,menarche age is positively related to FPG and 2hPG,the history of fetal macrosomia was negatively correlated with FPG and 2hPG.2.female parity associated with diabetes risk was increased.