Clinical Studies Of Knee Osteoarthritis With Effusion Treated By SiMiaoSanJiaWei

Objective: To observe clinical curative effect of knee osteoarthritis with effusiontreated by SiMiaoSanJiaWei, and to explore its action mechanism,and then to provideideas and methods for the clinical treatment of knee osteoarthritis with effusion.Methods: Randomly divide the78cases of patients who have knee osteoarthritiswith effusion and conform to the criteria for the diagnosis into treatment group(SiMiaoSanJiaWei)and control group(Xinhuang Tablet),each group with39cases, Thenthe treatment group was treated with SiMiaoSanJiaWei,while the control group withXinhuang Tablet. Pretreatment，treatment after two weeks and four weeks，the twogroups were observed and recorded the knee perimeter，the VAS score and WOMACindex,then all patients were observed the clinical curative effect.To statistic and analysisrelevant data with SPSS17.0statistical packages.Results: Both of treatment group and control group have obvious therapeuticeffects.The total effective rate of them is respectively89.7%and74.4%.Comparedbetween pretreatment,treatment after two weeks and four weeks,Both groups haveobvious statistical difference with the knee perimeter,the VAS score and WOMAC index(P＜0.01),It Suggests that the two drugs can both change the knee perimeter，the VASscore and WOMAC index.Treatment after two weeks,comparison on the knee perimeterand the VAS score between the observation group and control group has no obviousstatistical difference(P﹥0.05),but on the WOMAC index there was significances instatistics（P＜0.05）.Treatment after four weeks, comparison on the knee perimeter andWOMAC index between the treatment group and control group has obvious statistical difference(P＜0.01), but on the VAS score there was no significances in statistics（P＞0.05）.It suggested that the effect about treatment group change WOMAC index wasbetter than the control group. When it has been given more effectively treatment time,treatment group could get more significant change knee perimeter than control group.Two groups have the similar effect on improve the VAS score.There were no significantadverse reactions in two groups during the treatment.Conclusions： SiMiaoSanJiaWei have obvious therapeutic effects on treating kneeosteoarthritis with effusion. It can safely and effectively alleviate patients’ pain in thejoints, effusion, and improve the function of knee joint. Its action mechanism may be:todiminish inflammation,alleviating pain, inhibit synovial inflammation, reduce synovialeffusion; to regulating cell factors, improve the function of chondrocytes,and then delaycartilage degeneration;to improve local microcirculation, inhibit capillary permeabilityincrease and reduce pressure in the bone.