The Level Of Plasma Progranulin In Patients With Type2Diabetes Mellitus And Obesity And Its Role In Insulin Resistance

Objective：To detect plasma PGRN levels in healthy, obesity and newly diagnosedtype2diabetes mellitus(T2DM) subjects and to investigate the relationshipbetween plasma PGRN levels and glycolipid metabolism, inflammation andinsulin resistance.Methods：Eighty patients with newly diagnosed type2diabetes (T2DM) and88subjects with normal glucose tolerance (NGT) were recruited in the study.Both of them were divided into two subgroups respectively: normal weight(NW) subgroup and obesity (OB) subgroup. Obesity was defined as bodymass index(BMI)≥25kg/m2according to the World HealthOrganization-Western Pacific Region diagnostic criteria(2000). Body fatparameters were measured and BMI, waist-to-hip were evaluated.Meanwhile the levels of fasting plasma PGRN and IL-6were measured byELISA, fasting plasma glucose (FPG),2h plasma glucose (2hours after 75g OGTT test,2hPG), HbA1c, fasting insulin (FINS), and lipids were alsodetected. Insulin resistance (IR) and pancreas beta-cell function wereassessed by homeostasis model assessment (HOMA).Results:Plasma PGRN levels were significantly higher in T2DM group thanthose in NGT group（P<0.01）. Within groups of T2DM and NGT, plasmaPGRN levels in OB subgroup were significantly higher than those in NWsubgroup (225.22±34.39ng/mL vs195.59±50.47ng/mL and183.79±61.63ng/mL vs148.69±55.27ng/mL, P<0.05). Bivariate correlationanalysis showed that the plasma PGRN levels were positively correlatedwith weight, waist circumference, BMI, SBP, FPG,2hPG, HbA1c, TG, IL-6,FINS and HOMA-IR （P<0.05or P<0.01)，and were negatively correlatedwith HOMA-β (P<0.05). Multiple linear regression analysis showed thatBMI, HbA1c, IL-6and TG were independently related to plasma PGRNlevels(P<0.05).Conclusions：Plasma PGRN levels were higher in type2diabetes patients and obesitypatients respectively, and were closely related with glycolipid metabolism,chronic inflammation and insulin resistance.