| 1ObjectiveFrom the aspects of patients and rats of Insulin Resistance in type2diabetes(Insulin to hold, IR), blood sugar, glycosylated hemoglobin, C peptide, glucagon, tumornecrosis factor, the change of leptin and related laboratory index and acid GanJianYunprescription health spirit of Fried (Jianling Decoction, JLD) to its influence, to explorethe mechanism of action of the IR JLD therapy.2Methods2.1Clinical research64patients with insulin resistance in type2diabetes were randomly divided intocontrol group and treatment group,30cases in the two groups were routinely offer oralglucose-lowering therapy, western medicine treatment group on the basis of routinehypoglycemic treatment, add Fried by health spirit, two groups of a course of5weeks.Before and after treatment respectively calculate the total effective rate in both groupsand TCM syndrome integral, detect the fasting plasma glucose (FPG), blood sugar2hours after meal (2HPG), glycosylated hemoglobin (HbA1c), glucagon, tumor necrosisfactor, leptin secretion.2.2Experimental researchThe58male SD rats were randomly divided into two groups fed one week afterFITNESS: both normal10, high fat diet48. Select10as the control group of rats fed anormal diet, and the remaining40rats were fed a normal diet and high feed, each fed by25g+5g normal diet high libitum, four weeks after the high-fat diet rats were injectedintraperitoneally small doses of streptozotocin (STZ), induced rat model of type2diabetes. Will meet the diagnostic criteria of46rats were re-randomized into fourgroups: model group12,10and metformin metformin+Vita fried group, Jian Ling fryeach12. Normal group and model group were given normal saline control group was given metformin orally, the treatment group to be sour and sweet health movement inthe comparison group on the basis of the Qing Yang Jian Ling Huazhuo Recipe fried,were administered four weeks in a row. Observe the behavior of each group of rats,body weight, water intake, food intake, blood glucose, glycosylated hemoglobin(HbA1c), glucagon, tumor necrosis factor, leptin secretion.3Results3.1Clinical study resultsClinical observation showed that the healthy spirit and5weeks after treatmentcontrol group effective rate was53.3%, treatment group total effective rate was83.3%,the treatment group curative effect is better than that of control group (P <0.05), thecontrol group after treatment of TCM syndrome integral value of18.7±3.09, thetreatment group was15.9±2.96, improve TCM syndrome in treatment group is betterthan that of control group (P<0.05), two groups compared with before treatment groupalso had significant difference (P <0.01); Jianling decoction treatment group after theFPG,2HPG, INS, IRI, C-Peptide to improve before the treatment (P<0.05-P<0.01),INS, IRI has significant difference compared with control subjects (P<0.05); Thehealthy spirit decoction group LP, after treatment TNF alpha, Glucagon lower thanbefore treatment (P<0.05), all the indexes have significant difference compared withcontrol subjects (P<0.05); Jianling decoction group and before treatment and aftertreatment compared to the control group were improved significantly (P<0.05).3.2Experimental ResultsExperiments observed: Vita fried random group can effectively control bloodglucose, leptin, insulin, glucagon, C-peptide, tumor necrosis factor indicators (P <005.);Integrative Medicine group can effectively control leptin, insulin, glucagon, C-peptide,tumor necrosis factor index (P <005.), random blood glucose control for the effect ofIntegrative Medicine group is better fried ideal spiritual health; medicine group had nosignificant effect on the indicators above; blank and higher than the saline group, there were significant differences (P>0.05) in the control group weight metformin group andtreatment group, no significant difference (P>0.05) Integrative Medicine group.4. Conclusion4.1．Spleen liver stagnation, phlegm blocking the main pathological mechanisms IRtype2diabetes, the use of sour and sweet traditional Chinese medicine healthmovement to tone the liver and spleen, phlegm and blood type2diabetes IR method oftreating the symptoms of the new law, which consists of Vita fried with good treatmentof type2diabetes IR role. It is the body of diabetes by reducing insulin resistance andimprove insulin sensitivity and lipid metabolism, protect the islet B cell function, caneffectively relieve tension in vivo cortical secretion when blood sugar of varioushormones in order to achieve improved IR and lower blood sugar effect.4.2．Acid GanJianYun Fang Jianling decoction may improve insulin resistance in type2diabetes disease organism vascular endothelial cell function, delayed macrovasculardisease, suggesting that the mechanism may be related to secondary hypoglycemic,regulating fat metabolism, reduce LP, TNF-α, Glucagon levels thereby improvinginsulin resistance in type2diabetes and so on.. |
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