Peripheral Blood Stem Cell Transplantation For Patients With Acute Leukemia: Clinical Effects In50Cases

Objective:To evaluate the therapeutic effect of peripheral blood stemcell transplantation(PBSCT)for acute leukemia(AL), and to investigate theeffects and transplant-related mortality(TRM)of allogeneic(Allo-)PBSCTand autologous(Auto-)PBSCT.Discuss the selection and curative oftransplantation preparative regimen.Methods: Retrospective analysis fifty patients received PBSCT from2004to2012in our hospital,21patients are male, and the other is female.28patients were treated with Allo-PBSCT and22with Auto-PBSCT. Analysisof the effect of transplantation and complications.Compare the difference oftransplantation relapse rate,disease-free survival(DFS) and transplant relatedmortality(TRM).Analysis preparative regimen related death and successrate.Results:48patients engrafted successfully,the transplant success ratewas96%.The median time of white blood cell>0.5×109/L was and11.3(7-24)days,platelets>20×109/L was14.3(5-44)days.In follow-up time the probabilities of DFS for Allo-PBSCT and Auto-PBSCT were46.4%and35.0%,respectively;the probabilities of relapse were25.0%and55.0%,respectively;and the TRM were28.6%and15.0%,respectively.Follow-uptime the overall survival rate of Allo-PBSCT and Auto-PBSCT were57.1%and50%,respectively.Compare the state of CR1and≥CR2or NR in the twotherapies,overall survival rate were61.5%、53.3%and45.5%、55.6%;DFS were46.2%、46.7%and27.3%、44.4%; mortality rates were38.5%、46.7%and54.5%、44.4%,respectively.Conclusion:PBSCT is an effective means of treatment of acuteleukemia.Especially for patients with state CR1before transplantation,transplantation effect is better. Relapse rate of allogeneic transplantation islower than autologous transplantation,and long-term DFS is higher,but thetransplant related complications are more, mortality is higher.Except2casesof MAC preparative regimen implanted failure,All patients had not occurredpretreatment scheme related death.