| Objective: The purpose of the meta-analysis was to evaluate the efficacy and safety ofnarrow-band ultraviolet B combined with traditional Chinese herbal medicine for thetreatment of vitiligo, and provide reliable evidence based medicine for it treated the vitiligo.Methods: We searched relational literature from Wang Fang Data, CNKI, Pubmeddatabases about the narrow-band ultraviolet B combined with Chinese herbal medicine forthe treatment of vitiligo, and selected the literatures which were randomized controlledstudy, and extracted the relevant data. The quality of included trials was assessed by therandom allocation, blinding, withdrawals/dropouts and similar at baseline. We used Stata(version10.0; StataCorp, College Station, TX) conduct fixed-effects or random-effectsmodels meta-analysis to clinical cure rate and the efficiency, and the publication bias wereanalysis by using funnel plot.Results:13RCTs were enrolled in the meta-analysis. The quality of the literatures waslow.13studies weren’t serious side effects. The meta-analysis evidenced that the treatmentof vitiligo with narrow-band ultraviolet B combined with Chinese herbal medicine werehigher clinical cure rate in comparison to narrow-band ultraviolet B monotherapy (RR:1.56,95%CI [1.27,1.91], p=0.000) and Chinese herbal medicine alone (RR:1.96,95%CI [1.38,2.78], p=0.000), and there were higher efficiency compare to narrow-band ultraviolet B(RR:1.27,95%CI [1.10,1.46], p=0.001) and Chinese herbal medicine (RR:1.38,95%CI[1.12,1.69], p=0.002). All publication bias was less.Conclusions: The study has indicated that narrow-band ultraviolet B combined with Chinese Herbal medicine were higher clinical cure rate and the efficiency than usednarrow-band ultraviolet B or Chinese Herbal medicine monotherapy.13studies weren’tserious side effects. However, because of the lower quality of the literatures and less relatedforeign literatures, this conclusion need to confirm by further well-designed research. |
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