| Objective: Psoriasis is an immune disease of a T-cell disorder of polygenic inheritance. T-cell activation has a key role in the psoriatic process. Telomerase activity is closely related to T-cell proliferation and activation in psoriasis. Based on Chinese traditional medicine in which quite a lot of experiences have been accumulated in the treatment of psoriasis, our compound prescription aimed at removing heat from the blood and promoting blood circulation has got satisfied results in the treatment of psoriasis. The intention of this paper is to examine how the different dose increments affect the efficacy in the treatment of psoriasis vulgaris with narrow-band ultraviolet B radiation ,to observe the efficacy of treating psoriasis vulgaris by narrow-band ultraviolet B phototherapy combined with Chinese traditional medicine, to inspect telomerase activity in peripheral blood mononuclear cells of patients before and after the treatment of NB-UVB radiation, in order to investigate the optimal dose increment of NB-UVB radiation in the treatment of psoriasis, study new ways of NB-UVB combined with other treatments and the mechanism of NB-UVB radiation in the treatment of psoriasis.Methods: (1) In the optimization of radiation dose in the treatment of psoriasis vulagaris with narrow-band ultraviolet B radiation, 60 patients with psoriasis vulgaris were divided randomly into group A and group B. All the patients were treated with whole body NB-UVB radiation once in every two days with 0.4J/cm2 as the initial dose for every patient. For group A, 0.05J/cm2 was taken as the dose increment in the first five radiations, and afterwards, the dose increment was changed to 0.1J/cm2.
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