The Development Of A New Preparation For Angelica Mouldproof And Insect-resistant

Objective: This subject determine drug through mildew proof and insect preventionexperiment, and use decided turmeric, Biebersteinia heterostemon, radix sophoraeflavescentis, pepper four kinds medicinal materials for the research object. We conduct aseries of studies through component drug provided with mildew proof and insect preventionactive ingredient. Then conduct extraction process optimization and preparation molding etc.preliminary study for traditional Chinese medicine component drug. We establish the qualitystandard, and process preliminary stability estimation for preparation. Meanwhile researchpreparation acute toxicity combining modern pharmacology research foundation. Developmildew proof and insect prevention remarkable effect new preparation-Angelica sinensismildew proof and insect prevention micro emulsion spray and smoke agent to achieve aim ofthe task design.Methods:1. Choose20kinds of medicinal materials, then sift drugs and compatibilityproportion of mildew proof and insect prevention remarkable effect according to mildewcoefficient and insects damaged condition for indicators.2.Take component drug to water extraction and alcohol extraction. Next determinesuitable extracting solvent using mildew coefficient through mildew proof test.3. Optimize preparation extraction process using orthogonal experimental design methodaccording to curcumin content and dry paste rate for evaluation index.4. Single factor examination choose appropriate excipients surfactant and cosurfactant onthe basis of material properties and the stability of pseudo three phase diagram, drug andexcipients configuration; Choose suitable excipients, drug dosage and K value; Investigateappropriate preparation temperature. Complete soup preparation and tinning on the basis ofprotocolled preparation prescription to obtain mildew proof and insect prevention microemulsion spray.5. Choose suitable fuming excipients, ratio of drug and excipients according to excipientsproperties and fuming effect. Complete preparation and tinning according to protocolledpreparation prescription to obtain mildew proof and insect prevention smoke agent.6. Conduct TLC identified for turmeric of spray soup and smoke agent. Establish the content assaying method of turmeric through methodology examination.7. Research the stability of spray and smoke agent under the strong light irradiation, highhumidity and high temperature environment.8. Research the acute toxicity of soup and preparation.Results:1.We determine preparation drug which are turmeric, Biebersteiniaheterostemon, radix sophorae flavescentis, pepper. And compatibility proportion is1:1:1:1.2. Extraction solvent is75%alcohol; The optimum extraction process which orthogonalexperiment are: Component drug add75%alcohol of six times, then conduct reflux extraction3times, and each time is1.0h.3. Spray select excipients and dosage ratio. Soup: Polyoxyethylene35castor oil (EL35):Anhydrous ethanol: Water=3:27:13.5：66.5. Soup is oil phase. EL35is surfactant. Anhydrousethanol is cosurfactant. We stir at normal temperature.4. Smoke agent select excipients and dosage ratio. Soup: KCLO3：NH4CL：Talcumpowder: Bits of wood=1.4:1.75:2.2:3.0:1.4.5. Establish the quality standard of mildew proof and insect prevention spray and smokeagent. Methodology study shows that two kinds of preparation indicators all conform torequirements, and experimental data is stable and reliable.Conclusion: The process is reasonable and the data is reliable for mildew proof andinsect prevention spray and smoke agent; Molding process also achieves pharmacopeiarelevant requirements. It has the feasibility of industrial mass production at some extent.Complete a protocol of two kinds of preparation quality standard draft. It is concluded that thepreparation is low toxicity without excitant through proving research. It offers gist for plantpesticides applying to the storage of Chinese medicinal materials, and fixs a good basis for theresearch and development of vegetable pesticide new dosage form.