Clinical Studies Of Rheumatoid Arthritis With Interstitial Lung Disease

Object:Rheumatoid arthritis (RA) is a chronic progressive, systemic autoimmunedisease characterized by symmetry, multi-joint swelling, pain and deformity. Lung isconstituted by the rich connective tissue and blood supply, and is one of the frequentinvolvement of the organ, more than about50%of RA patients will involve the respiratorysystem, the most common of which is interstitial lung disease (ILD).There are no obviousclinical symptoms and signs in early time, with advanced pulmonary fibrosis, pleuraleffusion. Rheumatoid Arthritis Interstitial Lung Disease is the focus of attention in recentyears. The pathogenesis of RA involved a variety of cells，cells factors and Biologicalmacromolecules interact in the process and regulate the pathophysiological process of RA.Any of them can impact on the pathogenesis of RA．In this article, we collect clinicalmaterials of pure RA patients and RA-ILD patients，including general project，clinicalcharacteristics，laboratory examination，pulmonary function，imaging examination toexplore RA patients and RA-ILD patients clinical characteristics and other lab index toevaluate the relationship between RA and RA-ILD.Methods:Collected140RA patients’(79cases of patients with RA alone,61casespatients with RA-ILD) clinical features and laboratory parameters: ESR, CRP, RF,anti-cyclic citrullinated peptide (CCP), complement C3and C4, IgA,IgG, IgM, imagingstudies and pulmonary function, to analyze whether the statistical significance of thecomparison of these indicators in the2groups.Results:(1)Compared with pure RA group,the proportion of male, old age, smokinghistory and high titers of RF proportion of patients was higher, the difference wasstatistically significant (P <0.05).(2) RA-ILD patients was higher than that in the classification of joint function, X-ray installments, and erythrocyte sedimentation rate(ESR), CRP, and other indicators of RA patients, the difference was statisticallysignificant (P <0.05).(3) Compared to the immunological indicators of RA-ILD alone andRA patients, RF, complement C3and IgM comparison the difference was not statisticallysignificant (P>0.05), anti-CCP antibodies, complement C4, IgA and IgG compare thedifference was statistically significant (P <0.05).Conclusion:(1)Compared with the RA group, RA-ILD had a higher proportion ofpatients group in men, old age, smoking history and high titers of RF, suggesting that men,old age, smoking history and high titers of RF may be risk factors for RA patients withILD.(2)The number of patient in RA-ILD group is higher than RA group in joint functionclassification, X-ray stage, ESR, CRP, anti-CCP antibodies, complement C3, IgA and IgG,suggesting that ESR, CRP, anti-CCP antibodies, complement C3, IgA and IgG may berelated to the pathogenesis of RA-ILD.