| [Objective]:Type2diabetes, artery atherosclerosis, osteoporosis are metabolic diseases, which are often in combination in the same individual. By analyzing the influencing factors of the elderly type2diabetic patients with carotid atherosclerosis and bone mineral density, further to explore the relationship between carotid atherosclerosis and osteoporosis.[Methods]:Select200patients with type2diabetes of Kunming Medical University Second Affiliated clinical hospital, including108men,92women,aged≥60years (post-menopausal women over a year). Patients know and agree with the detection target. All subjects line neck vascular ultrasound, according to the IMT<1.0mm for the control group(No atherosclerosis), IMT≥1.0mm for the atherosclerosis group, and according to the characteristics of ultrasonic tissue echo,dividing the control group,soft plaque group, calcified plaque group, mixed plate groups. Subjects detect the bone mineral density through dual-energy X-ray bone density and are divided into groups with normal bone mass and bone mass group (osteoporosis and osteopenia).[Results]:1. Compared the control group with the atherosclerosis group, including age, body mass index, duration of diabetes,glycated hemoglobin levels, Fasting blood glucose,HOMA-IR level,indicators of lipid metabolism control, urinary albumin, uric acid, fibrinogen difference, statistically significant (P<0.05).2.The atherosclerosis group the chances of bone mass is higher than the no carotid control group, the difference was statistically significant (P<0.01).3.Compared the Male patients control group with the atherosclerosis group, the bone mineral density of the control group is higer than the experimental group, femoral neck, Ward’s triangle, all bone mineral density was statistically significant (P<0.05), trochanter was no significant difference between the two groups (P=0.05); female patients control group and the atherosclerosis group BMD:bone mineral density in the control group is higher than the atherosclerosis group, L1, L2, L3, L4,L1-4BMD difference was statistically significant (P<0.05) between the two groups(P>0.05).4.Various parts of BMD and IMT line Pearson correlation analysis showed that female patients L1, L2, L3, L1-4, male patients with femoral neck, Ward’s triangle BMD and carotid IMT was negatively correlated (r=-0.305,-0.370,-0.287,-0.349,-0.433,0.297,-0.243, P <0.05).5. Compared the control group with the soft plaque, calcified plaque and mixed plaque four group, there is a difference about age, duration of diabetes,body mass index, glycosylated hemoglobin, urine albumin, cholesterol,low-density lipoprotein cholesterol, and the difference is statistically significant (P<0.05).6.Soft plaque, calcified plaque group and mixed plaque of male patients which the bone mineral density were lower than the control group, the difference was statistically significant (P<0.05); Soft plaque group, calcified plaque group, mixed of female patients which the bone mineral density were lower than the control group, the difference was statistically significant (P<0.05).7.To compare the largely calcified group with control group、the soft group with control group and the mixed plaque group with control group respectively after adjusting for age, SBP, TG, TC, LDL-C, FPG and other carotid porridge the plaques the risk factors, we found that the loss of bone mineral density was closed correlation with the incidence rate of carotis calcified plaque(P<0.05), however, the loss of bone mineral density was nothing to do with the incidence rate of both carotis soft plaque and fibrous.8. With or without bone mass changes as the dependent variable in multivariate logistic regression analysis indicated that age, duration of diabetes,HOMA, TC, TG, LDL-C, UA, calcified plaque is an independent risk factor for loss of bone mineral density, BMI is a protective factor.[Conclusion]:1.Carotid artery atherosclerosis and bone mineral density are closely related to elderly type2diabetic patients.2.Age, blood glucose, insulin resistance, hyperlipidemia, duration of diabetes, uric acid, urinary albumin are common factors which affect bone mineral density and carotid artery atherosclerosis of diabetes.3.The loss of bone mineral density was a negative correlation with the incidence rate of carotis calcified plaque(P<0.05), however, the loss of bone mineral density was nothing to do with the incidence rate of both carotis soft plaque and fibrous.4.Age, duration of diabetes,HOMA, TC, TG, LDL-C, UA, the calcified plaque is an independent risk factor of reducing bone mass, BMI is a protective factor. |
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