| Objective1. To observe the correlativity between the age, the gender of the patients with type2diabetes mellitus, the course of the diabetes, and the diabetic nephropathy (DN);2. To observe the correlativity between the Body Mass Index (BMI) and the Waist-to-Hip Ration (WHR) of the patients with type2diabetes mellitus and the DN;3. To observe the correlativity between the blood pressure of the patients with type2diabetes mellitus include the systolic pressure and the diastolic pressure and the DN;4. To observe the correlativity between the blood-fasting sugar (BFS), the glycosylated hemoglobin (HBAIC) of the patients with type2diabetes mellitus and the DN;5. To observe the correlativity between the total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) of the patients with type2diabetes mellitus and the DN,6. To observe the correlativity between the fasting insulin (Fins), fasting c-peptide (FCP) of the patients with type2diabetes mellitus and the DN;7. To observe the correlativity between the uric acid (UA) of the patients with type2diabetes mellitus and the DN.Methods756patients with type2diabetes mellitus were elected. Then gather the relevant clinical data:include the name, gender, age, the course of the diabetes of the patients; and measure the body mass, body height, BP, waistline, hipline etc of the patients; draw blood from the vena mediana cubiti on an empty stomach, then measure the FBS, TC, TG, HDL-C, LDL-C, UA, HbAlC, Fins, FCP. Record the urine amount of24hours of the patients, and measure the microalbuminuria, then divided the patients into3groups according to the urinary albumin excretion rate (UAER), the UAER<20ug/min were defined as the group without DN (A group),20μg/min<UAER<200μg/min were the group with DN have low UAER (B group),and UAER≥200μg/min were the group with DN have high UAER (C group). Analyse and compare the above index belong to the3groups, and use the multivariate logistic regression to detect the relevant factors about the DN.Results1. The case rate of the diabetes with nephropathy is30.2%in the756cases of patients with type2diabetes mellitus.2. The correlativity between the age, gender, the course of the diabetes of the patients with type2diabetes mellitus and the DN:The gender is undifferentiated in the3groups; the age and the course of the diabetes in the patients with DA (B and C groups) are significant higher than the patients without DN (A group)(P<0.05); the age and the course of the diabetes in the patients with DN have high UAER(C group) are significant higher than the patient with DN have low UAER (B group)(P<0.05). The multivariate logistic regression show that the course of the diabetes is related with the occurrence of the DN.3. The correlativity between the BIM, WHR of the patients with type2diabetes mellitus and the DNThe BMI and WHR of the patients in the group without DN (A group) and the groups with DN (B and C groups) are not significant difference, but the multivariate logistic regression show that the BMI is related with the occurrence of the DN.4. The correlativity between the BP (include the systolic pressure and the diastolic pressure) of the patients with type2diabetes mellitus and the DNIn the basic data of the patients, the systolic pressure and the diastolic pressure of the patients with DN (B and C groups) are significant higher than the patients without DN (A group)(P<0.05); the systolic pressure and the diastolic pressure in the patients with DN have high UAER(C group) are significant higher than the patient with DN have low UAER (B group)(P<0.05). The multivariate logistic regression show that the systolic pressure is related with the occurrence of the DN (P<0.001).5. The correlativity between the FBS, HbAlC of the patients with type2diabetes mellitus and the DNThe FBS and the HbAlc have significant difference between the group with DN have low UAER (B group) and the A group (P<0.05), The FBS between the group with DN have high UAER (C group) and the A group have significant difference (P<0.05), the FBS and the HbAlc have no significant difference between the group with DN have high UAER (C group) and between the group with DN have low UAER (B group). The multivariate logistic regression show that the FBS, HbAlC are related with the occurrence of the DN (P<0.001).6. The correlativity between the TQ TC, HDL-C, LDL-C of the patients with type2diabetes mellitus and the DNThe content of the TG, HDL-L have significant difference between the groups with DN (B and C groups) and the group without DN (A group)(P<0.05),the TG, TC, HDL-C have significant difference between the group with DN have low UAER (B group) and the A group (P<0.05),the above index have no significant difference between the group with DN have high UAER (C group) and between the group with DN have low UAER (B group),but when use the multivariate logistic regression, the TG, TC, HDL-C, LDL-C are not included in the equation, can not reveal the occurrence of the DN is related with the lipid metabolism disorder.7. The correlativity between the Fins, FCP of the patients with type2diabetes mellitus and the DNThe Fins, FCP have significant difference between the group with DN have low UAER (B group) and the A group (P<0.05), the Fins, FCP have significant difference between the group with DN have high UAER (C group) and the A group (P<0.05), the Fins> FCP have significant difference between the group with DN have high UAER (C group) and the group with DN have low UAER (B group)(P<0.05). Use the multivariate logistic regression, the Fins、FCP are not included in the equation, can not reveal the occurrence of the DN is related with the Fins, FCP.8. The correlativity between the UA of the patients with type2diabetes mellitus and the DNThe UA between the group with DN have low UAER (B group) and the A group have significant difference (P<0.05), The UA between the group with DN have high UAER (C group) and the A group have significant difference (P<0.05), the UA between the group with DN have high UAER (B group) and the group with DN have low UAER (B group) have significant difference (P<0.05). The multivariate logistic regression show that the UA is related with the occurrence of the DN (P<0.001).ConclusionThe occurrence of the DN is the result of the multi-factor’s combined action, the age, course of the diabetes, systolic pressure, diastolic pressure, FBS, TG, HDL-C, UA, Fins, FCP of the patients are the predisposing factors of the occurrence of the DN. The course of the diabetes, BMI, systolic pressure, HbAlc, FBS, UA are related with the occurrence of the DN, and the course of the diabetes, FBS,UA are the most important risk factors. |
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