| Objective:1.To explore the relationship between demographic characteristics, body mass index and DN in patients with type 2 diabetes mellitus;2. Patients with type 2 diabetes mellitus in blood pressure (systolic blood pressure, diastolic blood pressure), fasting blood glucose (FBS), postprandial blood glucose (PBS), glycosylated protein (HbA1C), blood red blood cholesterol (TG), high density lipoprotein cholesterol (HDL-C), triglyceride (TC), low density lipoprotein cholesterol (LDL-C), blood uric acid (UA), homocysteine (HCY) and the correlation between the level of DN;3. Analysis of the correlation between C reactive protein (CRP) and DN in patients with type 2 diabetes mellitus.Method:Chose the patients treated in the Department of endocrinology in the Third Affiliated Hospital of Qiqihar Medical School from March 2015 to December 2015 with WHO diagnostic criteria in type 2 diabetes, according to urinary albumin excretion rate is divided into simple diabetes mellitus group and early diabetic nephropathy group, clinical diabetic nephropathy group. The investigators fill in the questionnaire according to the clinical data, collected data including gender, age, duration of diabetes, systolic blood pressure, diastolic blood pressure, body mass index (BMI), fasting blood glucose (FBG), postprandial blood glucose (PBS), LDL-C low density lipoprotein cholesterol, blood red blood cholesterol (TG), high density lipoprotein cholesterol (HDL-C), triglyceride (TC), glycosylated protein (HbA1C), C reactive protein, blood uric acid and blood homocysteine status. We used SPSS 13.0 system to make data entry and analysis. A statistical description of the measurement data is expressed by χ±μ, count data use rate or constituent ratio; among the multiple groups were compared with variance analysis, measurement data usingvariance analysis or rank sum test, count data using chi square test; using logistic regression analysis of factors influencing diabetes mellitus. P<0.05 indicates that it has statistical significance.Result:1 The prevalence of diabetic nephropathy was 31.1% in 2 patients with type 354 diabetes mellitus patient.2 The gender, age, course of disease and the correlation between the duration of disease and the diabetic nephropathy.The gender composition ratio between the three groups was not statistically significant. The average age of the patients with diabetic nephropathy group (2 and 3) was higher than that in the simple diabetes group (group 1), but no statistical significance. Compared with diabetic group (F=65.682, P<0.05),the course of diabetic nephropathy was statistically significant. Multivariate logistic regression analysis showed that the course of disease was related to the occurrence (OR=1.338,95%CI=1.242-1.442).3 Comparison of body mass index (BMI) in each group.There was no significant difference between the simple diabetic group and the diabetes nephropathy group. Multivariate logistic regression analysis showed that the height was negatively correlated with the occurrence of diabetic nephropathy.4 Correlation between blood pressure and glucose nephropathy in patients of each group.Compared with simple diabetic group, the systolic blood pressure and diastolic blood pressure were significantly different from diabetic nephropathy (χ2=21.747,P< 0.05; χ2=7.831,P<0.05).Multivariate logistic regression analysis showed that systolic blood pressure was correlated with the occurrence of diabetic nephropathy (OR=1.024,95%CI=1.005-1.043).5. Correlation of smoking history, drinking history, history of hypertension, family history of diabetes with diabetic nephropathy in each group.There was no difference in smoking history between the three groups by χ2 test. There was no difference in drinking history between the three groups by χ2 test. However, multi factor Logistic regression analysis showed that drinking was related to the occurrence of sugar nephropathy. There was no difference in the history of hypertension between the three groups by χ2 test. There was no difference in the family history of diabetes between the three groups by χ2 test.6. Fasting blood glucose (FBS), postprandial blood glucose (PBS) and glycosylated hemoglobin (HbAlC) were compared in each group.The fasting blood glucose in the diabetic nephropathy group was higher than that in the simple diabetes group (F=7.707,P<0.05), which was statistically significant. The postprandial blood glucose in the diabetic nephropathy group was higher than that in the simple diabetes group (F=2.367,P< 0.05), which was statistically significant. The diabetic nephropathy group and the simple diabetes group (F=5.714,P<0.05) were statistically significant. Multivariate logistic regression analysis showed that postprandial blood glucose was correlated with the occurrence of diabetic nephropathy(OR=1.120,95%CI=1.045-1.201).7. Correlation of cholesterol, triglyceride, high density lipoprotein, low density lipoprotein with diabetic nephropathy in each group.The level of cholesterol in diabetic nephropathy group was higher than that in the simple diabetes group (F=0.128,P<0.05). Multivariate logistic regression analysis showed that cholesterol was associated with the occurrence of diabetic nephropathy. Compared with the simple diabetes mellitus (F=2.752,P<0.05), the triglyceride in the diabetic nephropathy group was significantly higher than that in the diabetic group. The high density lipoprotein in the diabetic nephropathy group was significantly higher than that in the simple diabetes group (F=8.839,P<0.05). There was no statistical significance between simple diabetic group and diabetic nephropathy group with low density lipoprotein. Multivariate logistic regression analysis showed that low density lipoprotein was associated with the occurrence of diabetic nephropathy.8. Comparison of homocysteine, C-reactive protein and serum uric acid in each group.The same type of homocysteine in patients with diabetic nephropathy was higher than that in the simple diabetes group, but not statistically significant (F=28.525,P>0.05). The C-reactive protein in the nephropathy group was higher than that in the simple diabetes group, but there was no statistical significance (F=0.416,P>0.05). The serum uric acid of diabetic nephropathy was higher than that of the simple diabetes group (F=19.114,P<0.05), and there was statistical significance. Multivariate logistic regression analysis showed that serum uric acid was correlated with the occurrence of sugar nephropathy(OR=1.007,95%CI=1.003-1.011).Conclusion:The prevalence of diabetic nephropathy in the study population was higher. The occurrence of diabetic nephropathy is a multi factor, the three groups of patients with systolic blood pressure, diastolic blood pressure, drinking history, history of hypertension, height, duration of disease, FBS, PBS, HbA1C, TG, HDL, HCY, UA, there are differences. The logistic regression analysis revealed that the occurrence of DN was related to the occurrence of. Age, course of disease, drinking history, body height, systolic blood pressure, postprandial blood glucose, cholesterol, occurrence of low density lipoprotein, blood uric acid, blood homocysteine and glucose related nephropathy risk factors, except age and height than for diabetic nephropathy. |
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