Pulse Through The High-sugar High-fat High-cholesterol Diet Dm Rat Femoral Artery Endothelial Dysfunction And Related Factors

Objective: To investigate the effect of Maitongfang on certain related factors which can cause DLASO, mainly on the effect on glycometabolism, lipometabolism, oxidative stress and function of blood platelet. Methods: The SD rats were fed with high-sugar, high-fat and high-cholesterol diet, and then induced by Alloxan intraperitoneally to be diabetic rat models. The rats were randomly divided into five groups, ie. Model control, low dosage of Maitongfang, high dosage of Maitongfang, and Cilostazol group respectively. Normal control group was also established. The effect of different medicines on the following parameters were detected by radioimmunoassay, biochemistry method, Histomorphometry, etc. which were level of insulin, TC, TQHDL-C,Lp (a) ,SOD, MDA, ET, NO, TXB2,6-Keto-PGF1a, tectology of femoral artery, changes in general condition and blood glucose as well. Results: The abnormality of most of the parameters stated above were shown in DM rats, as well as the pathologic changes of femoral artery. While Maitongfang demonstrates the action of improving the general condition, adjusting the metabolism of blood glucose and blood lipid, strengthening the cell's ability of antioxidation, correcting the dysfunction of endothelium, improving the function of platelet aggregation. The comprehensive curative effect of Maitongfang is superior to that of Cilostazol group. Conclusion: Through the regulating action of many pathways and links which presented as alleviating or eliminating damnification on Tunica intima of artery by above factors, Maitongfang contributes to the prevention and treatment of DLASO by intervening the very first step of DLASO.