Study On Single Syndrome Analysis And Characteristics Of The Phlegm Syndrome Distribution Of Primary Liver Cancer

Objective:The goal of this research is to analyze the Chinese medical syndromes of primary carcinoma of the liver, and to probe distribution characteristics of phlegm syndrome of PLC, so that a reference of the dialectical criteria of PLC can be provided.Methods:Cross-sectional survey was undertaken in this study.The questionnaire of PLC was designed accordding to clinical trial guidelines of TCM investigational new drug and experts’ opinions. Medical Records were collected at Oncology outpatient department of Xiyuan Hospital of China Academy of Chinese Medical Sciences from Jan,2011to Apr,2013. Then the cases were subjected to TCM syndrome differentiation. Statistics description and analysis were made base on the data.Results:l.The rank (from high to low) of the five single syndromes of PLC are Qi stagnation(199,54.2%),spleen-deficiency syndrome(182,49.6%), blood stasis syndrome (129,35.2%), damp-heat syndrome(117,31.9%),Yin deficiency syndrome (103,30.9%). Combination of these single syndromes make up the common composite syndromes of PLC.2.127PLC patients (34.6%)were diagnosed with single syndromes, while240patients (65.4%)were diagnosed with complex symptoms. The constituent ratio rank (from high to low) is blood stasis and spleen deficiency and Qi stagnation(14.7%), spleen deficiency and Qi stagnation and Yin deficiency(14.2%),spleen deficiency and Qi stagnation(11.2%), damp-heat and blood stasis(9.5%).3.The most common clinical manifestations of the367PLC patients include fatigue(60.6%), weight loss(55.3%),gloomy complexion(52.9%).abdominal distension (52.6%). loss of appetite(50.6%),hypochondriac pain(50%),upset stomach(48.9%), dark urine(43.8%). distractedness (41.3%). insomnia (40.7%).4.There were116cases met the diagnostic criteria of phlegm syndrome, accounting for31.6%of the total367patients.5.Blood stasis(38.5%) was the most common syndrome which combined with phlegm syndrome in single syndromes, this was followed by spleen-deficiency syndrome(31.4%). Spleen deficiency and Qi stagnation and Yin deficiency(51.9%) was the most common syndrome which combined with phlegm syndrome in complex symptoms, followed by damp-heat and Yin deficiency(48.4%), Qi stagnation and blood stasis(29.6%), spleen deficiency Qi stagnation and blood stasis(29.6%).6.Frequency of occurences of the phlegm syndrome in patients with different clinical stages were distinct.The rank of the frequency was tend to stageEⅢ> stageⅡ> stageⅡ. Tumour-bearing patients who diagnosed with phlegm syndrome were more than non-tumour patients(p=0.0076<0.05). The frequency of occurences of the phlegm syndrome among patients with different tumor morphology had no statistical difference (p=0.2496>0.05). There were no statistical differences in the AFP,GGT between the two groups(p>0.05).Conclusions:l.Qi stagnation syndrome is the most common types in PLC single syndromes, followed by spleen-deficiency syndrome. Spleen deficiency and Qi stagnation and blood stasis is the most common type in PLC complex syndromes.2.Accounting for1/3of the total patients can diagnosed with phlegm syndrome. Blood stasis is the most common syndrome which combined with phlegm syndrome in single syndromes, followed by spleen-deficiency syndrome. Spleen deficiency and Qi stagnation and Yin deficiency is the most common syndrome which combined with phlegm syndrome in complex symptoms, followed by damp-heat.3.The frequency of phlegm syndrome is higher when clinical stage is later.There were no statistical differences in the tumor morphology, AFP and GGT between the two groups.