A Correlation Study Of HR-HPV And Cervical Cancer And Precancerous Lesions In The Occurrence And Prognosis

Object： To explore the correlation of high-risk human papillomavirus (HR-HPV) andvarying degrees of cervical lesions and prognostic.Methods：Our hospital high-risk HPV positive and patholigical diagnosis of cervical lesionsin1158patients,grouped according to the patholigical diagnosis:①Low-grade squamousintraepithelial neoplasia(LSIL)group,including chronic cervicitis and CIN Ⅰ;②High-gradesquamous intraepithelial neoplasia(HSIL)group,including CINⅡ~Ⅲ,cervical squamous cellcarcinoma(SCC);The patients of more CINⅡand CINⅠimpossible to be follow up were treatedwith surgical therapy. After3,6,9,12,18and24months treatment of follow-up underwentHPV,cytology.Results：①HPV infection rates were54.5%,72.0%,91.1%,96.1%for chronic cervicitis,CIN I, CIN II to III and cervical cancer respectively, HPV infection rate difference wasstatistically significant (χ~2=157.054, P<0.05), and was positively correlated with the severityof cervical lesion(r=0.362, P<0.05);②Grouped by age, at all levels of the cervical lesionsHR HPV-loads by comparing multiple samples rank and inspection, the difference hadstatistical significance (P <0.05). And with the increase of level of cervical lesions, HR HPVcapacity has increased significantly;③With the increase in HPV load, also increased the risk ofcervical lesions;④HR-HPV infection rate in every age group（35years old or less,36~,50years old or more）there was no statistically significant difference (χ~2=4.973, P>0.05). Age35years old or less as the control group, each group viral load in36~,>50years old age groupthe OR values were1.446,1.414,1.475,1.469,1.475,1.469, and are all greater than1, butbecause of the95%ci also contains1, did not reach significant statistical significance.⑤HR-HPV load level before treatment does not affect the prognosis of CIN I, CIN II to III andcervical cancer, HR-HPV continuous positive will predict the exist of cervical lesions aftertreatment.⑥HPV negative rate of different treatments have significant difference（χ~2=10.461,P＜0.05）.Interferon group with the other three groups were statisticallydifferent(P＜0.05).⑦No significant difference between cervical conization and hysterectomyof CINⅡ~Ⅲ patients（χ~2=0.505,P＞0.05）.⑧HPV negative rate has nothing to do with thelevels of cervical lesions(P＞0.05).⑨HPV-negative rate in every ege group is91.38%、90.91%、77.27%（χ~2=7.254,P＜0.05）⑩HPV clearance time of chronic cervicitis and CINⅠ,CINⅡ~Ⅲ,SCC group median were7,7,4months（χ~2=6.799， P＜0.05）.Conclusion：①HR-HPV infection is the main cause of cervical pathological changes occurat all levels. HR-HPV infection rate increased with the level of cervical lesions.②HR-HPVcapacity levels were positively correlated with the severity of cervical lesion, and a significantdose-response relationship, HR-HPV loads are major risk factors of cervical pathologicalchanges at different levels.③the region may have no obvious correlation of HPV infection and age, age is likely to be suffering from CINⅡor more disease risk factor, but the study did notreach statistical significance, so it cannot be concluded that "age is a major risk of CINⅡormore disease".④HR-HPV load level before treatment does not affect the prognosis of CIN I,CIN II to III and cervical cancer, HR-HPV continuous positive will predict the exist of cervicallesions after treatment.⑤patients with different treatment can effectively remove the HR HPVinfection, and surgical treatment more effective than interferon treatment.⑥No significantdifference between cervical conization and hysterectomy of CIN Ⅱ~Ⅲ patients.⑦HPVnegative has nothing to do with the level of cervical lesions.⑧Age is a Related factorof HPVnegative.⑨HR-HPV negative time is different at all levels of cervical lesions after differenttreatment,cervical cancer patients is the shortest time and may be linked to cervical cancerpatients with operation range is large enough to have as much as possible, in addition to thecause of residual or recurrence of cervical lesions.