Study On The Correlation Between High Grade Squamous Intraepithelial Neoplasia Of Cervix And Human Papilloma Virus Infection

Objective:(1)Statistical analysis of the distribution of HPV infection before treatment in HSIL patients with high-risk human papilloma virus(HPV)infection;(2)HPV conversion rate and its change rule were reexamined 3,6,12,18,24 months after cervical conization;(3)Comparison of HPV infection in patients infected with HPV16/18 type and other 12 types of high-risk HPV infection after HPV infection negative rate difference;(4)The difference of HPV negative conversion rate after cervical ring electrotomy and cold scalectomy for HSIL.Methods: Collected from January 2017 to December 2019 months in Xiangxi Autonomous Prefecture People’s Hospital diagnosis of cervical high-grade squamous intraepithelial lesion in patients with general condition,operation method and the result of preoperative and postoperative review of HPV,select the line of patients with cervical cone cut method,statistical preoperative and postoperative 3,6,12,18,24 months review results of HPV and were retrospectively analyzed.Results:(1)The number of patients diagnosed with HSIL without HPV infection after surgery accounted for 7.7%,the number of patients with HPV infection accounted for 92.3%,among which the number of patients with HPV type 16 or 18 accounted for 24.10%,and the number of patients infected with other 12 high-risk types of HPV alone accounted for75.90%,with HPV type 52 in the majority;(2)Patients with HPV infection with cervical high-grade squamous intraepithelial lesions underwent cervical coning after 3,6,12,18,24 months of HPV negative conversion rates were 24.7%,31.7%,45.7%,58.6%,69.9%,(3)respectively,and the HPV negative conversion rates of patients with HPV16/18 type infection after 3,6,12,18,24 months of HPV were 13.3%,17.8%,31.1%,46.7%,66.7%,respectively.The negative HPV conversion rates of patients who were simply infected with the other 12 high-risk HPV types were 28.4%,36.2%,50.4%,62.4% and 70.9% at 3,6,12,18 and 24 months after surgery,respectively.The postoperative negative conversion rate of patients with HPV16/18 type infection was lower than that of patients with other 12 types of high risk HPV infection alone,while there was no statistical significance in the negative conversion rate of HPV16/18 type infection and other high risk HPV types 18 and 24 months after surgery(P > 0.05).(4)the cervical cold knife resection after 3,6,12,18,24 months HPV overcast rate were 24.4%,30.1%,43.1%,55.3%,65.9%,cerical annular cutting postoperative 3,6,12,18,24 months HPV overcast rate were 25.4%,34.9%,50.8%,65.1%,77.8%,below the cervical HPV overcast rate after resection of the cervical cold knife annular cutting overcast rate,but there was no statistically significant difference(P > 0.05).Conclusion:(1)Most of the HSIL patients were associated with HPV infection,among which the other 12 high-risk types of infection were the main ones in this region;(2)The negative conversion rate of HPV infection in HSIL patients with high-risk HPV infection after cervical coning was increased with prolonged postoperative recovery time.The negative conversion rate of HPV infection with HPV type 16/18 was lower than that with HPV infection with other 12 high-risk HPV types,and the difference was insignificant after 1 year.(3)The surgical method had no significant effect on the negative conversion rate of HPV after operation.