| Objective To approach the clinical significance of the high-risk human papillomavirus (HR-HPV) in the follow-up of cervical cancer and precancerous lesions.Methods Follow-up using HPV-DNA testing (HC-2) and thin-layer liquid-based cytology (LCT) on 174 patients,whose postoperative histological diagnosis was cervical cancer or precancerous lesion.Results LWith standard treatment, After 1 month,3 months,10 months,22 months of follow-up, HR-HPV-DNA test results can predict residual or recurrent lesions, and it's positive predictive value was 23.9%,30.8%,55.2%,45.7%, respectively;the negative predictive values were all 100%.2.After follow-up,there were 8 cases who had residual or recurrent lesions in both precancerous lesions group and cervical cancer group. After 1 month,among HR-HPV positive persons of the two groups, the residual disease or recurrence rates were 18.2%(8/44),34.8%(8/23); after 3 months were 21.1% (8/38),57.1%(8/14); after 10 months were 42.1%(8/19),80.0%(8/10); after 22 months were 42.1%(8/19),50.0%(8/16).3.After 1 month,3 months,10 months,22 months of follow-up, HPV-negative rates of the patients who had cervical conization was 65.0%,68.9%,87.2%, 86.7%,respectively;the rates of the patients who had hysterectomy were 63.2%,70.6%, 75.0%,79.4%;and the rates of the patiens who had radical hysterectomy were 53.0%,71.0%,80.0%, 67.0%.Conclusions 1. HR-HPV-DNA detection plays an important role in cervical cancer and cervical intraepithelial neoplasia's follow-up.2.The surgical modes for different levels of disease can removal HPV infection effectively. However,it perhaps takes some time,about 10 months.3.After treatment,the HR-HPV-positive patients should been intervened in oder to reduse the residue or recurrence.
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