| Objective: We can confirm the relation between eczema and food-sIgG, identifythe positive rate of food-sIgG through detecting food-specific IgG (food-sIgG) ininfantile eczema. Then we can analyze the influence of complementary feeding andfamily history for allergy on the positive rate of food-sIgG. To explore the effective rateafter dietary regulation, we make a plan about dietary regulation in some patients witheczema.Thus we could find out the etiology, prevention and treatment about eczemareasonably.Methods: All the patients of infantile eczema came from Dalian Children’sHospital allergy clinic from October1st2010to September30th2011. According to thecomplementary feeding and family history for allergy, the patients were divided intotwo groups respectively.On the basis of patients’ visiting time, we selected forty caseswith positive result of food-sIgG, these cases were evenly randomized into groups fordietary regulation. Fourteen kinds of food-sIgG were detected by enzyme-linkedimmunosorbent assay (ELISA) method, the person responsible for the test strictlyfollowed the instruction book and read the value at450nm in the microplate reader.Then the result was divided into four levels: the value less than50U/ml is negative, theclassification is ’0’; the value between50and l00U/ml is mildly sensitive, theclassification is ’+1’; the value between100and200U/ml is moderately sensitive, theclassification is ’+2’; the value more than200U/ml is highly sensitive, the classificationis ’+3’. General treatment was applied to the patients without dietary regulation, thedietary regulation was according to the classification of food-sIgG on the basis ofgeneral treatment. We examine or call every patient once after one month, three months,six months of the results, every patient had three follow ups.The patient should visit thedoctor whenever the eczema reappeared. We can calculate the effective rate of eczema with the standard of clinical effect.Results:1. The general condition: we collected120cases that correspond with thestandard of infantile eczema from October1st2010to September30th2011,82malesand38females, the average age was17months.2. The positive rate of food-sIgG was (116/120)96.7%in120patients of infantile eczema. Among fourteen kinds of foods, the positive rate was the highestfor milk(87.5%), then followed by egg(74.2%), soybean(33.3%), tomato(27.5%),wheat(24.2%), the result of highly sensitive was common in milk and egg. Thepositive rate was the lowest for mushroom(1.7%) and pork(1.7%).3. In the eczema patients with positive food-sIgG, constituent ratio of one itempositive food-sIgG was (18/116)15.5%, two items positive food-sIgG were(35/116)30.2%, three items positive food-sIgG were (22/116)19.0%, four and more thanfour items positive food-sIgG were (41/116)35.3%.4. The positive rate of food-sIgG was (92/93)98.9%in the patients with thecomplementary feeding, and it was (24/27)88.9%in the patients withoutcomplementary feeding, the positive rate in the former was higher than the latter, therewas significant difference among the two groups by Chi-square test (P<0.05).Thepositive rate of the patients with the complementary feeding was higher than thepatients without complementary feeding in egg, rice, soybean and tomato, there wassignificant difference by Chi-square test (P<0.05).5. The positive rate of food-sIgG was (87/89)97.8%in the patients with thefamily history for allergy, and it was (29/31)93.6%in the patients without the familyhistory for allergy, there wasn’t significant difference among the two groups byChi-square test (P>0.05).6. Every patient had three follow ups after one month,three months,six months ofthe food-sIgG results,the effective rate was10.0%,57.9%,88.2%in the patients withdietary regulation, and it was5.0%,10.0%,25.0%in the patients without dietaryregulation. With time prolonged in6months, the effective rate of eczema wouldincrease gradually. But the increasing degree in the two groups was different, the groupwith dietary regulation was much higher. There wasn’t significant difference in theeffective rate after one month(P>0.05), but there was significant difference after threemonths and six months(P<0.05). Conclusion:1. There is close relationship between infantile eczema and food-sIgG, thepositive rate of food-sIgG is as high as96.7%.Food-sIgG can refer to many kinds offoods,four and more than four items positive food-sIgG are the most. Food-sIgG may beone of important factors of infantile eczema.2. The primary foods that lead to positive food-sIgG of infantile eczema in Dalianare milk(87.5%),egg(74.2%),soybean(33.3%) and tomato (27.5%).3. Family history for allergy of the eczema patient has nothing to do with thepositive rate of food-sIgG.4. The positive rate of the eczema patient with the complementary feeding ishigher than without it in Dalian, and egg, rice, soybean, tomato are the primarycomplementary feeding.5. With time eczema can alleviate gradually in6months, and the effective ratemay be increased obviously with dietary regulation. |
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