Effect Of Insulin Treatment On EBA Expression In Diabetic Cognitive Impairment Rat

Objective: To determine whether diabetic cognitive impairment associates withblood-brain barrier injury.And the effect of insulin therapy.Methods:52health grown-up male SD （Sprague-Dawley） rats divided into2big groups stochastically:1month group（n=26）and3month group（n=26）; Eachgroup then divided into3groups stochastically: diabetic group （n=10）, insulintreatment group （n=10） and control group （n=6）. Diabetic rats were induced bystreptozotocin injection. All the rats were under the test of Morris water maze on1month and3months following diabetes onset, after which the expression of EBA wereobserved separately.Results:EBA experession： Compared with control group and insulin treatment grope,1month diabetic rats group had no statistical difference （P＞0.05）3monthsdiabetic rats grope and insulin treatment group had decreased expression of EBA infrontal lobe basal ganglia, hippocampus and white matter nearby lateral ventricle （P＜0.05）.Conclusion:1. Blood brain barrier damage is one of the reasons in diabetic cognitiveimpairment.2. The early insulin application can delay the diabetic cognitive impairment,but can not prevent the occurrence of cognitive impairment.