The Correlations Of Insulin Resistance And Cognitive Impairment

Background--All we know, Insulin resistance is a risk factor for pre-diabetes and type 2 diabetes mellitus, A large number of existing research results aslo show that its increaseing risk of cognitive impairment, even Alzheimer’s disease.Furthermore,most patients with Alzheimer’s disease arise fasting glucose impaired and insulin resistance. Obove all, it is affirmatively that a close correlation exist between insulin resistance and cognitive impairment.Objectives--To explore the relationship between insulin resistance and cognitive impairment, And learn more about the risk factors for cognitive impairment, in order to find direction of reduce cognitive dysfunction.Methods--Selected 100 medical personsand type 2 diabetes inpations from the First Affiliated Hospital of Fujian Medical University from Oct 2013 to Oct 2014 who meet with the inclusion criteria,which included 49 males and 51 females, aged from 46 to 83 years old,and average age is 64.5 ± 9.0 years old.Patients be grouped according to “insulin resistance syndrome”diagnostic criteria proposed by the Chinese Medical Association Diabetes Society(CDS).We collected the clinical datas, such as glycated hemoglobin(Hb A1C), fasting glucose, TG, TC, HDL-C,LDL-C, and body mass index(BMI).The cognitive function of Fifty eight patients with insulin resistance(test group) and forty two non-insulin-resisters(control group) were evaluated used internationally accepted Mini-Mental Status Scale(MMSE) and Montreal Cognitive Rating Scale(Mo CA) score to evaluate their cognitive function.The chi-square test, independent samples test and logistic regression analysis were used for statistical analysis.Results--1.the mean scores of Insulin resistance group(including MMSE and Mo CA text) was significantly lower than non-insulin resistance group(P<0.05).2.Defined Mo CA score <26 points as cognitive dysfunction(MCI),Insulin resistance group had 41 cases of MCI patients(70.7%), non-IR group had18 cases of MCI patients(42.86%);Defined MMSE score<27 points as cognitive dysfunction,the MCI patients insulin resistance group was 25(43.1%), the MCI patients of non-insulin-resistant group of 7(16.7%).To Sum up,the detection rate of cognitive dysfunction in insulin resistance group was significantly higher than that in non-insulin-resistant group.3.Cognitive function scores in patients with diabetes lower than non-diabetic patients,the detection rate of MCI in diabetes group was significantly higher than that in non-diabetes group.4.Logistic regression analysis showed that OR value was 0.286 via the MMSE score method, meaning that good glycemic control patients possibility of cognitive impairment are 0.286 times of poor glycemic control patients.The OR value was 0.313 via the Mo CA score method, meaning that good glycemic control patients possibility of cognitive impairment are 0.313 times of poor glycemic control patients.Conclusions--diabetes mellitus and Insulin resistance are highly correlated with cogniti- ve impairment,who can promote the occurrence of cognitive impairment.In addition, cognitive impairment positively correlated with glycated Hemgolobin(Hb A1C), poor glycemic control is an important risk factor for cognitive impairment.