The Effect Of Berberine Hydrochloride On The Levels Of Large Platelet Ratio In Patients With Acute Cerebral Infarction

Objective: We observed the large platelet ratio in peripheral blood in patientswith acute cerebral infarction of before berberine treated and after. To discuss therelationship among the coagulation function, large platelet ratio and the NIHSS scores,moreover, to explore the cerebral protective effect of berberine and its probablemechanism of pathophysiology.Methods: Select49patients with acute cerebral infarction for CI group, and51healthy patients for control group. Both were satisfied the standard of gender and agecomposition(P>0.05).According the different method, we divided the cerebral infarctionpatients into berberine group and common group, and they were comparable in thecomposition of the gender, age and NIHSS scores(P>0.05).We used the sysmexXE-5000analyser made in Japan to detect the PLCR in peripheral blood. SysmexCA-6000full-automation analysis meter made in Japan is used to explore thecoagulation function.Measure the change of PLCR in acute cerebral infarction patientswithin48hours of onset and the first10days after admission. For the patients withacute cerebral infarction, neurologic deficits degree were assessed in pathogenesiswithin48hours of onset and the first10days by the U.S. National Institutes of HealthStroke Scale(NIHSS) scores.SPSS11.5was used to detect all data, and the test ofsignificance level for bilateral is the inspection P<0.05.Results:1.The PLCR in peripheral blood in group with acute cerebral infarction the first10days after admission were significantly higher than those in group with health people,but with the level of within48hours of onset they were no significant difference.2.The large platelet ratio had no correlation with the NIHSS scores in the cerebralinfarction group. The PLCR within48hours of onset has significant positive correlation with the APTT level at the same time(P<0.05),but the negative correlation with the FIBlevel of the same time and the PT level of the second times(P<0.05).The level of PLCRof the first10days after admission has significant negative correlation with the TT levelof the first times.3.The PLCR in peripheral blood of the patients with the common groups the first10days after admission were significantly higher than those within48hours of onset,but in the berberine group the PLCR in peripheral blood of the two times have nosignificant difference.4.The NIHSS scores between the common groups and the berberine groups withinthe48hours of onset have no significant difference. But the NIHSS score with theberberine groups in the first10days after admission is significant decreased than thosewith the common groups.Conclusion:1.The PLCR in peripheral blood of the group with acute cerebral infarction weresignificantly higher than those in group with health people，and large platelet may beinvolved in the pathophysiology of cerebral infarction.2.The PLCR in peripheral blood of the group with acute cerebral infarction hadsignificant positive correction with the level of FIB、PT and TT, and had significantnegative correction with the level of APTT. Thus, it is prompting that the familiarcorrection between PLCR and coagulation function in the mechanism ofpathophysiology in patients with acute cerebral infarction.3.Berberine could restrain the increase of the PLCR in peripheral blood with acutecerebral infarction. Prompting that berberine could influence the platelet function andcoagulation function.4.Berberine could improve the quality of the CI patients and had neuroprotectiveeffect.