Related Analysis Of The Clinical Features In Children With Primary Nephrotic Syndrome

Objective Retrospective analysis of the clinical characteristics and related factors is to improve the clinical understanding of the disease early, the standard treatment programs, improved efficacy, and to improve the long-term prognosis, so as to provide useful help to the diagnosis and treatment of children with the PNS.Method Collected609cases of children with the PNS from January2008to December2011in our hospital pediatric inpatient,with the general clinical data and analysis of the characteristics, the characteristics of clinical classification complications, clinical type and age gender, pathological type, serum albumin, cholesterol, D-dimer, a24-hour urine protein, the first course and treatment to ease the time, the clinical features and their correlationResults1.The average age of all the patients was6.64±3.61years old, and5-7year-old was as the most common age in our study. The ratio of male and female was2.1:1.438cases of simple type NS was accounted for71.92%;171cases of nephritis NS was accounted for28.08%.2.The average age of the simple type NS was76.22±43.96months and305 cases (69.6%) was male,133cases (30.4%) was female., The average age of the nephritis type NS was86.16±42.02months and male107cases (62.6%), female64cases (37.4%). Age and gender had no significant different in simple type NS and nephritis NS (P>0.05).3.The amount of serum albumin, total cholesterol, D-dimer, and urine protein negative days formal hormone therapied, were considered statistically significant between the two groups in our study(P<0.05). The admission total cholesterol and D-dimer assay values of the nephritis NS was higher than the simple type NS, but lower serum albumin. Regular hormone therapied, was more likely to be alleviated the condition.4.The complications of the PNS in children corrected infections, electrolyte imbalance, thrombosis, acute renal failure and other (hypovolemic shock, hypertensive encephalopathy). The most common complication was infection,518cases (85.06%); the electrolyte disturbances followed by250cases (41.05%); thrombosis was153cases (25.12%); acute renal failure was96cases (15.76%); hypovolemic shock and hypertensive encephalopathy was less by48cases (7.88%).The complications had statistically significant different in simple type NS and nephritis NS (P<0.05). Nephritis NS complications was significantly higher than the simple type NS.5. In our study, the management organization of kidney disease showed that the MCNS was more common (50%), followed by MSPGN (26.3%), MN relatively rare (2.6%). The simplex type MCNS ratio significantly was higher than the nephritis type in children(P<0.05). But the Other pathological types was no significant correlation in the clinical classification of the PNS(P>0.05).6. To the treatment of urinary protein positive,the statistical analysis had significant difference between the simplex type NS and the nephritis type NS (P <0.05). The proteinuria was more negative to the Simple type NS.(The simplex type NS need12.33±8.24days, but the nephritis type NS need17.15±7.18days.)Conclusion1.The prevalence peak age of the PNS in children was5-7years old, and the male is significantly higher than female.2. Age and gender had no significant different in simple type NS and nephritis NS.3. The admission total cholesterol and D-dimer assay values of the nephritis NS was higher than the simple type NS, but lower serum albumin.4. The most common pathological type of PNS was MCNS.The simplex type MCNS ratio significantly was higher than the nephritis type in children. But the Other pathological types was no significant correlation in the clinical classification of the PNS.5.The complications of the PNS in children corrected infections, electrolyte imbalance, thrombosis, acute renal failure and hypovolemic shock, hypertensive encephalopathy.Nephritis type NS complications was significantly higher than the simple type NS.6. A long time should be needed for the remission of the nephritis NS. The proteinuria was more negative to the Simple type NS.