Primary Nephrotic Syndrome Clinical Pathology Study On Correlation Between TCM Syndrome

Objective:To understand the Guangdong area suffering from clinical features of primary nephrotic syndrome (PNS) of all ages crowd, pathological type, TCM Syndrome Distribution and further explore the correlation between patients with PNS and pathological types of syndrome of TCM and clinical indexes and age.Methods:A total of 227 patients with PNS from March 2010 to were selected from the clinic of the central clinic and ward of the Provincial TCM renal biopsy in March 2015. The medical history, pathological typing, biochemical parameters, TCM syndromes and relevant information were collected and analyzed by SPSS18.0 software.The epidemiological characteristics, biochemical indicators, TCM syndromes and renal pathological types of the selected cases were analyzed and compared.. The correlation between the TCM Syndromes of TCM and renal pathological types and the clinical indexes was analyzed by age stratification.Result:1.227 cases of PNS cases, TCM syndrome of Asthenia Type in deficiency of Yang of the spleen and kidney, Yang deficiency of spleen and kidney in 95 cases (41.8%), Qi deficiency of spleen and kidney in 54 cases (23.8%), deficiency of both qi and Yin in 30 cases (13.2%),24 cases of lung and kidney qi deficiency (10.6%), yin deficiency of liver and kidney in 24 cases (10.6%) in order. Renal pathological types in Mn, in turn MN119 (52.42%) cases, MCD61 (26.87%) cases, MsPGN21 (9.25%) cases, FSGS19 cases (8.37%), MPGN7 patients (3.08%) and between TCM syndrome of Asthenia Type and the renal pathological types without statistical difference.2. In 227 cases of PNS, the FSGS was higher than that of MsPGN, MN and Scr, and BUN was FSGS Compared with the MCD, MN, BUN, the MsPGN was higher, the FSGS was higher than that of UA, and the difference of MCD was statistically significant compared with the 24h-Upro of MN.3. In 227 cases of PNS, liver and kidney yin deficiency with respect to the higher Tg of deficiency of both qi and Yin; deficiency of Spleen Yang and Kidney Yang with respect to the Qi and yin deficiency, Qi deficiency of spleen and kidney SCR higher; Yang deficiency of spleen and kidney with respect to the Qi and yin deficiency, Qi deficiency of spleen and kidney bun is relatively high; Yang deficiency of spleen and kidney with respect to the higher UA of deficiency of both qi and Yin; deficiency of Spleen Yang and Kidney Yang with respect to the liver kidney yin deficiency, Qi deficiency of spleen and kidney TC higher; Yin deficiency of liver and kidney compared with deficiency of both qi and Yin TG is higher, the difference is statistically significant.4. In 227 cases of PNS, TID integral is equal to or more than 2 points in turn FSGS 15 cases (78.9%), MN51 cases (42.9%), MPGN3 cases (42.9%), MsPGN5 cases (23.8%), MCD8 cases (13.1%). Glomerular global sclerosis percentage is more than or equal to 10%, followed by FSGS14 (73.7%), MN38 patients (31.9%), MsPGN4 patients (19%), MCD9 patients (14.8%). MPGN1 cases (14.3%), the difference between the two groups have statistical significance.5.119 cases of MN, TID integral is equal to or more than 2 points, followed by qi deficiency of spleen and kidney in 9 cases (45%),7 cases of deficiency of both qi and Yin (43.7%),24 cases of Yang deficiency of spleen and kidney (43.6%),5 cases of lung and kidney qi deficiency (41.7%), yin deficiency of liver and kidney in 6 cases (37.5%); glomerular global sclerosis percentage is more than or equal to 10% followed by spleen and kidney yang deficiency in 23 cases (41.8%),8 cases of qi deficiency of spleen and kidney (40%), Yin deficiency of liver and kidney in 4 cases, Qi deficiency of lung and kidney in 3 cases (25%),3 cases of deficiency of both qi and Yin (18.7%). There was no significant difference between the groups.6.119 cases of MN patients, TID score more than 2 in order for the 40-65 age group in 32 cases (43.8%), more than 65 groups of 7 cases (43.7%),14-40 group of 11 cases (36.7%). The percentage of more than 10% glomerular global sclerosis were more than 657 cases (43.7%),14-40 group of 10 cases (33.4%), 40-65 group of 21 cases (28.8%). There was no significant difference between the groups.7. In 61 patients with MCD, TID integral is equal to or more than 2 points in turn for the spleen kidney yang deficiency syndrome (3 cases) and lung and kidney qi deficiency (1 case),14.3%, Qi deficiency of lung and kidney 1 case (5%), yin deficiency of liver and kidney and deficiency of both qi and Yin were 0 cases; glomerular global sclerosis percentage is more than or equal to 10% followed by Yang deficiency of spleen and kidney in 6 cases (28.6%), yin deficiency of liver and kidney in 1 case (20%), Qi deficiency of spleen and kidney in 2 cases (10%), lung and kidney qi deficiency, deficiency of both qi and Yin were 0 cases. There was no significant difference between the groups.8. Among the 61 patients with MCD, the TID score of 40-65 was high, and there were 4 cases (33.3%) in TID score. The second is 14.-40 years old in 4 cases (8.4%), more than 65 years old in 0 cases. In glomerular global sclerosis percentage, is more than or equal to 65 year old heavy, is more than or equal to 10% with 1 cases (100%), followed by 40-65 years old in 3 cases (25%),14-40 years old in 5 cases (10.4%). There was no significant difference between the groups.9. In 14-40 years old group, spleen and kidney qi deficiency is the most common,39 cases (17.2%), followed by the spleen and kidney yang deficiency in 32 cases (14.1%), deficiency of both qi and Yin in 17 cases (7.5%), lung and kidney qi deficiency in 12 cases (5.3%), liver kidney yin deficiency in 9 cases (3.9%); in 41.-65 years old group, spleen and kidney yang deficiency were the most common,52 cases (22.9%), followed by the spleen and kidney qi deficiency in 14 cases (6.2%), deficiency of both qi and Yin in 12 cases (5.3%), liver kidney yin deficiency in 11 cases (4.8%), lung and kidney qi deficiency in 10 cases (4.4%), was more than or equal to 65 years old group of spleen and kidney yang deficiency were the most common,11 cases (4.8%), followed by liver and kidney yin deficiency in 4 cases (1.8%), lung and kidney qi deficiency (0.9%), deficiency of both qi and Yin (0.45%), spleen and kidney qi deficiency (0.45%). Conclusion:1.227 cases of PNS cases, the type of TCM syndrome is spleen deficiency, spleen kidney yang deficiency. The renal pathological type was MN, followed by MCD.2.227 PNS cases, Scr, BUN, UA, FSGS were higher, and the 24h-Upro of MCD was higher.3.227 cases of PNS, Scr, BUN, spleen kidney yang deficiency UA, TC high; Yin deficiency of liver and kidney in high TG.4. In 227 cases of PNS, the TID score of FSGS and the percentage of global sclerosis were higher.5. In the case of MN, the TID score of the spleen and kidney yang deficiency and the global sclerosis of the glomerular were higher6. In the case of MCD, spleen kidney yang deficiency and lung kidney qi deficiency TID integral is higher, spleen kidney yang deficiency glomerular global sclerosis percentage is higher7. In 14-40 years old group, Qi deficiency of spleen and kidney of the most common, followed by spleen kidney yang deficiency; in 41-65 years old group, Yang deficiency of spleen and kidney of the most common, followed by qi deficiency of spleen and kidney; in more than or equal to 65 years old group spleen kidney yang deficiency is most common.