The Correlation Between Parkinson’s Disease And Lipids,Living Habits In Lvliang Rural Area Of Shanxi Province

Background Parkinson’s disease (PD) is an age-related progressive neurodeg-enerative disorder and is one of the causes that lead disability in the elderly. The typical neuropathological characteristic is the selectively neuronal degenera-tion, loss and significant decrease of Dopamine (DA) in dopaminergic substant-ia nigra parscompacta.In addition the surviving neurons cytoplasm appeares fi-broblast-like eosinophilic Lewy body. The main clinical manifestations of PD include bradykinesia, rigidity, tremor and gait instability. Currently PD can onl-y rely on medication to control the symptoms, but unable to slow disease pro-gression in clinic. The quality of life of patients reduce, also brings great me-ntal and economic burden, so PD is being paid more and more attention.Objective To observe the correlation of Parkinson’s disease (PD) and lipids, living habits.Methods The case-control study was population-based. According to the cur-rent international main etiology hypothesis and the possible risk factors of PD, we developed a structured questionnaire of risk factors. Information on name, gender, age, height, weight, smoking habits, drinking tea history and fasting blood sample were obtained from the people over the age of55living in Lvli ang rural areas of Shanxi province. Well trained investigators conduct a reasear-ch to the object face-to-face using a standard questionnaire "scale" and the re-unification of the9problems of risk factors of structured questionnaires. The suspicious PD is diagnosed by expert by asking medical history and auxiliary examination. We choose30cases finally diagnosed and30controls matched on nationality, residence, gender and age with cases.We collect the basic infor-mation and fasting lipid results. Statistics is analysised by t test and χ2test, the level of the test is0.05, P<0.05had significant difference. Results1. The cases is made up of21males and9females.The mean age is74.1±8.32years old; the controls is made up of20males and10females and the mean age is73.7±8.02years.2. The characteristics (gender, age, education level and body mass index) of cases and controls have no significa-nt difference (P>0.05).3. The TG, TC, HDL-C and LDL-C of cases and co ntrols have no significant difference (P>0.05); stratificating for smoking, the lipids levels between the two groups have no significant difference yet(P>0.05);4. Smoking was negatively correlated with PD (P<0.05);5. Drinking tea or a lohol have no significant differences with PD (P>0.05).Conclusion1. TG, TC, HDL-C and LDL-C may have nothing to do with the onset of PD;2. Smoking is protective factor of PD;3. Drinking tea or al-ohol may have no correlateion with PD.