Study About Clinical Features And Influence Factor Of Prognosis For Molecular Typing Of Breast Cancer

Objective: Through case viewing, sum up the clinical and pathological features of molecularsubtypes from breast cancer patients cured in our hospital in recent5years,to discussregulation and parts distribution of molecular subtypes from breast cancer.Interviewing thepatients,investigating their living condition to discuss negative factors of molecular subtypesfrom breast cancer and to provide theoretical reference to clinical treatment and prognosisestimation.Method: To select1273patients that are diagnosed breast cancer in GeneralHospital of Ningxia Medical University from Jan.2007to Jun2012which were finaldiagnosis by pathohistology and had completed follow-up data of five years.All of thepatients are women. The classification of breast cancer was according to the immunohisto-chemical results of estrogen receptor(ER),progesterone receptor(PR) and human epidermalgrowth factor receptor-2(HER-2) status.Via calling re-examination and interviewing thepatients to analysis parts distribution and clinical pathological features, recurrence andmetastasis as well survival of molecular subtypes from breast cancer. Using single andmultiple statistical methods to analyze the survival of breast cancer. Result:1.Totally1273cases of breast cancer was Luminal A subtype accounted for12.90%Luminal B subtype60.87%,HER-2over-expression subtype10.05%and triple negative subtype16.96%.2.Luminal type was likely to occur in age from35to50, accounted for58.44%、49.42%, mostof pathohistology type were invasive ductal carcinoma.The histologically grade were wellaccounted for86.35%,74.19%. Luminal A and Luminal B subtype tumor size T1and T2wereaccounted for98.05%,96.00%and less lymph node status,with low stage disease. HER-2over-expression and triple negative subtype was likely to occur in age35,accounted for 14.84%,7.87%.The histologically grade were advanced accounted for91.41%,90.27%. HER-2over-expression and triple negative subtype tumor size T2and T3were accounted for59.38%,50.93%and more lymph node status,with advanced stage disease were accountedfor71.09%,64.35%.There are significantly different with repect to age,menopausal status,family history,tumor size, lymph node status, stage disease,and in different subtypes,and inhistological type, nation and primarily site have no statistical significance.3.171cases ofrecurrence or distant metastasis,compare to the non-triple-negetive group, the triple-negetivegroup transfer rate of relapse and metastasis(P<0.05),especially the internal transfer rate andbrain metastases is higher(P<0.05). The5-year overall survival rates(OS) and the5-yeardisease-free survival(DFS) rate for patients with Luminal A,luminal B,HER-2and triplenegative breast cancer were84.1%and80.00%,82.2%and71.80%,64.3%and60.70%,59.10%and54.50%,there were significant difference (P<0.05).4. The5-year overall survival rates used singlefactor of Kaplan-Meier shows that age, pathological type, tumor size, lymph node the stagewere general factors of molecular subtypes from breast cancer (P<0.05).Using multiple causesCox regression to analyze these factors, which shows molecular subtypes, tumor size andlymph node are independent factors of breast cancer. Conclusions:1. Each subtype of breastcancer have its own specific clinical features, Luminal B is the highest proportion, followedby triple negative and Luminal A type, the proportion of HER-2over-expressing is the least.2.Luminal type from breast cancer usually with elderly age,most of them were invasive ductalcarcinom which has low malignant,Luminal type had the best prognosis.Triple negative breastcancer usually had a tumor of larger size and more lymph node status,with advanced stagedisease,which had the worst prognosis.3.Molecular subtypes were independent factors ofbreast cancer.