| Objective: SCCC is one kind of gynecologic malignant tumor,the incidence of this tumor is very low.Accounts for about 0.31% ~ 2% of cervical malignant tumor,A high degree of malignant,belong to the neuroendocrine type.The main diagnostic basis is pathological and immunohistochemical examination.The human papilloma virus lead to cancer and has close relationship with small cell carcinoma of cervix. The disease can lead to lymph node metastasis and blood line spread easily and earlier,he prognosis is poor,FIGO stages as the main independent factors affecting of the prognosis.Therefore,early and accurate diagnosis is crucial for the prognosis of patients. Taking the comprehensive treatment as the principal thing,surgery combined with chemotherapy and radiotherapy.The chemotherapy is mainly VAC/PE, radiotherapy as auxiliary treatment,the aim is to prolong the survival time. This study,Hebei Medical University were retrospectively analyzed the clinical data and follow-up data of 6 years of carcinoma of the cervix.The SCCC was compared with squamous cell carcinoma.Discussing the clinical and pathological features of SCCC and the factors of affecting the prognosis of small cell carcinoma of cervix.Methods: The study,select the clinical data of small cell carcinoma of cervix and squamous carcinoma of the cervix treated in the Forth Hospital of Hebei Medical University from January 1,2008 to July 28,2012.All patients treated by the operation and confirmed by the pathology somethings immunohistochemistry,also making perfect follow-up data.The following up deadline is on July 31,2014.Imaging examination,tumor makers and clinical manifestation as the diagnosis standard of disease recurrence.One team was composed by 18 patients with small cell carcinoma of cervix,At the same time, 40 patients with cervical squamous carcinoma as control group were randomlyselected in the same period.Collecting the clinical data of two groups,to compare the differences of age, clinical stage, tumor size,lymph node metastasis rate,vascular tumors bolt, and the median survival.Analysis the factors of affecting prognosis of small cell carcinoma of cervix. SPSS13.0 software package was used to analysis statistical data.Using chi-square test, chi-square calibration test and Fisher probabilities test to analysis enumeration data. These mothers can analysis differences between the group and the control group.The survival rates were calculated by Lapland-Meier method. Single factor the difference of survival rate and the survival curve comparison using the log-rank method to detect. Multiple factors analysis using Cox regression model.Statistical differences were indicated by P<0.05.Results: 1 The age distribution of small cell carcinoma of cervix was 25~72 years old, the median age was 39.The age distribution of squamous carcinoma of the cervix was 34~66 years,the median age was 47 years.The comparison of two groups with median age has no difference. 2 The small cell carcinoma of cervix and squamous carcinoma of the cervix of the clinical symptoms were compared to place of residence, pregnant time, production time, abortion history and history of marriage.two groups were no statistically significant difference(P>0.05). 3 The small cell carcinoma of cervix and squamous carcinoma of the cervix of clinical stage I are respectively 72.2%,82.5%. There was no statistically significant difference comparison with two groups(P>0.05). 4 The small cell carcinoma of cervix and squamous carcinoma of the cervix with lymphatic metastasis are respectively 44.%, 15%,the small cell carcinoma of cervix with lymphatic metastasis transport rate was high,.There was statistically significant difference comparison with two groups(P<0.05). 5 The small cell carcinoma of cervix and squamous carcinoma of the cervix with vascular tumors bolt are respectively 38.8%, 10%, the small cell carcinoma of cervix of vascular tumors bolt rate was high.There wasstatistically significant difference comparison with two groups(P<0.05). 6 The small cell carcinoma of cervix and squamous carcinoma of the cervix were compared in tumor size,cervical stroma invasion depth,near the palace infiltration, vaginal stump invaded. The difference of all aspects are not obvious. There was no statistically significant difference comparison with two groups(P>0.05). 7 The small cell carcinoma of cervix and squamous carcinoma of the cervix of recrudesce rate are respectively 33.3%,7.5%,the small cell carcinoma of cervix of recrudesce rate was high.There was statistically significant difference comparison with two groups(P<0.05). 8 The small cell carcinoma of cervix and squamous carcinoma of the cervix of 3 years of survival rate were respectively 61.1%,92.5%.There was statistically significant difference comparison with two groups(P<0.05). 9 Single factor analysis:clinical stages,lymph node metastasis,vascular tumor bolt,and the size of the lump are the factors influencing prognosis(P<0.05).Cervical small cell pathological types of isolated type and mixed type are compared,also immunohistochemical expression of Cg A are compared,the former survival rates are low, but there was no statistically significant difference comparison with two groups(P>0.05).Multiple factors analysis: age,clinical stage,tumor size,stromal infiltration depth,lymph node metastasis,vascular tumors bolts are not the independent risk factors influencing the prognosis of small cell carcinoma of cervix.Conclusions: 1 The small cell carcinoma of cervix is a highly malignant neuroendocrine tumor,its prognosis is poor.The prognosis is good when the stage is early,In order to improve the situation by strengthening health education to women,and parallel before cervical cancer screening.It has important clinical significance for treatment of carcinoma if it was found early. 2 Compared to patients with cervical squamous cell carcinomas, the small cell carcinoma of cervix of pathological features is age of onset moreyounger,mainly early vascular tumors, lymph node metastasis rate,and the occurrence rate was high. 3 The small cell carcinoma of cervix and cervical squamous cell carcinomas are no obvious difference was found in clinical characteristics. 4 Clinical stages, lymph node metastasis, vascular tumor bolt, and the size of the lump are the risk factors influencing the prognosis of the small cell carcinoma of cervix. Age, interstitial infiltration depth, pathological type, protein(Cg A) expressions are not independent risk factors affect the prognosis of cervical small cell. |
PDF Full Text Request