Analysis Of Clinicopathologic Characteristics And Prognosis Of27Male Patients With Bteast Cancer

Objective:This study is aimed to evaluate the clinicopathological features, treatment protocols and survival of male patients with breast cancer, and to explore the prognostic factors for male breast cancer (MBC)Methods:Clinical data of27patients with MBC, who were histopathologically confirmed and treated at Shandong Provincial Hospital and Qilu Hospital of Shandong University between June2000and Septenmber2012, were collected. The log-rank test and COX regression model were used to evaluate the prognostic factors for MBC. The clinicopathologic features, locoregional re-currence rate, metastatic rate, and5-year survival rate were retrospectively analyzed. The general and clinicopathological characteristics including age, site of tumor, location of tumor, histological type, estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor2(HER-2), surgery, adjuvant chemotherapy, adjuvant radiotherapy, adjuvant endocrine therapy, tumor size, lymph node status, distant metastasis and TNM stage were investigated by univariate analysis to evaluate the impact of these factors on patient survival.Results:1) Infiltrating ductal carcinoma was the predominant pathological subtype, accounting for96.3%.The positive rates of ER, PR, and HER-2were96.3%,92.6%, and5%, respectively.2) Mass in the breast was the major initial sign in100%patients and was mainly located in the areola area, accounting for55.6%.3) About88.9%patients received modified radical mastectomy,59.3%received adjuvant chemotherapy,37%patients received adjuvant radiotherapy, and74.1%received endocrine therapy.4) The5-year overall survival rate of27patients was64.3%. The5-year disease free survival rate was57.1%. The5-year overall survival rates for stage Ⅰ, Ⅱ, Ⅲ, and Ⅳ were87.5%,50%,33.3%, and0. The5-year disease free survival rate for stage Ⅰ, Ⅱ, Ⅲ, and Ⅳ were87.5%,50%,0, and0.5) About7.4%patients suffered locoregional recurrence, and11.1%of patients had distant metastasis.6) Univariable analysis showed that tumor size, clinical TNM staging, axillary lymph node status and surgical procedure significantly influenced the overall survival. Tumor size, clinical TNM staging, axillary lymph node status significantly influenced the disease free survival.7) Multivariable COX regression analysis showed that the tumor size, axiilary lymph node status and surgical procedure were independent prognostic factors of overall survival for MBC. And the tumor size and surgical procedure were independent prognostic factors of disease free survival for MBC.Conclusion:(1) The characteristics of Chinese MBC include a predominant pathological subtype of infiltrating ductal carcinoma, higher expression rate of ER and PR and lower expression rate of HER-2.(2) The tumor size, axiilary lymph node status and surgical procedure were independent prognostic factors of overall survival for MBC. And the tumor size and surgical procedure were independent prognostic factors of disease free survival for MBC.(3) Early diagnosis and radical mastectomy-based comprehensive treatment are essential to improve the survival of patients with MBC.