To Investigate Procalcitonin Guidance Value And Significance On Infant Pneumonia Severity And Prognosis

Background and ObjectivesPneumonia is the most common respiratory disease in children, infants inthe winter and spring pneumonia onset more, if the treatment is not complete,it’s easy to repeated attacks, cause a variety of severe complications, andthreaten the health of children. Bacteria are important pathogens causingpneumonia in children, compared with developed countries, bacterial pathogens ismore important in the etiology of pneumonia in developing countries.therefore,bacterial pneumonia in infants must be taken seriously enough,the commonpathogen is streptococcus pneumoniae,staphylococcus aureus and haemophilusinfluenzae. The bacterial pneumonia condition in infants is special, coupledwith the physical of pediatric, pediatric disease has changeable, the rapidcharacteristic, if not timely diagnosis, it’s easy to delay in treatment and howearly identification of bacterial pneumonia in infants and young children, inorder to make the correct and prognosis of the disease judgment, preventinflammation and exacerbate disease progression, clinical pediatrician becomean important issue in the treatment of pneumonia. The study found thatprocalcitonin has a high sensitivity and specificity of the new infection markersin the early diagnosis of the disease, to determine the severity and prognosis, etc. obvious advantages, has become a hot research. In this study, PCTguidance for detection of bacterial pneumonia in infants condition assessmentand prognosis.At present, procalcitonin on infection of bacterial pneumonia inchildren has less research.This study select50cases of bacterial pneumonia inchildren to explore PCT guidance for the detection of bacterial pneumonia ininfants assessment and prognosis of the disease.Materials and MethodsSelect from October2012to November2013bacterial pneumonia in childrenhospitalized infants50cases, including31males and19females, all childrenbetween the ages of45days-3years, mean (1.5±0.4) years of age.Selected childrencollect various physiological parameters and laboratory test reports within24h ofhospitalization the results (for pulse, respiration, blood pressure, arterial oxygenpressure, pH, sodium, potassium, hemoglobin, creatinine or blood urea nitrogen,gastrointestinal manifestations10indicators) the worst rating value was critically ill,the highest score was94points, the lowest score was72points. According to theresults of pediatric critical illness score was divided into ordinary pneumonia andsevere pneumonia group two groups. A total of34cases of ordinary pneumoniagroup, accounting for68%; severe pneumonia in16patients (32%).All patientswere admitted on the first day (acute phase) and after treatment when the diseasecured or improved (recovery) venous blood, blood circulation PCT test, parallel PCTand pediatric critical illness score (PCIS) were analyzed. PCT test results under bothdivided <0.5ng/mL,0.5-2.0ng/mL,2.0-10.0ng/mL,>10.0ng/mL4groups, eachgroup comparing children with antibiotic use and hospitalization time, parallelperipheral culture. Statistical analysis was performed using SPSS17.00statisticalsoftware, data results mean±standard deviation,count data usingχ2test, Pearson correlation using range analysis, measurement data using analysis ofVariance, P <0.05was considered statistically significant.Results150cases of bacterial pneumonia in children hospitalized on day1(acute phase) PCT testing positive rate was82%.With the control andremission of inflammation,PCT convalescent positive rate dropped to10 percent,Statistical difference was statistically significant (P <0.05).2Analysis of PCT and PCIS score correlated: there was a significant negativecorrelation between PCT and PCIS score (r=-0.67, P <0.001).350children with bacterial pneumonia, acute phase of severe pneumoniaPCT results were0.5ng/ml or more, there were two cases>10ng/ml,significantly higher than ordinary pneumonia, the difference was statisticallysignificant,(P <0.05).4.PCT levels and blood relationship to determine the condition andprognosis indicators: With the PCT values increased use of antibiotics inchildren with bacterial pneumonia and prolonged hospitalization time.5PCT levels and blood culture test results:50cases of bacterial pneumoniain children with infantile blood culture detected three cases of Haemophilusinfluenzae infection,2cases of pneumonia bacterial infections,1casesStaphylococcus aureus, bacterial detection rate of12%.With the PCT valuesincreased, blood culture positive rate increased.ConclusionsProcalcitonin as an evaluation index, the disease of bacterial pneumonia ininfants assessment, prognosis and guide the application of antibiotics havesome clinical significance.