The Meta-analysis On The Effect Of GnRH Analog (GnRHa) In Prevention Of Premature Ovarian Failure During Chemotherapy

Purpose: The use of GnRH analog (GnRHa) to preserve ovarian function has beeninvestigated in several small studies. We performed a systematic review of studiesexamining whether a GnRHa administered during chemotherapy is protective ofovarian function and fertility.Methods:Using database included PubMed，Spring，Ovid，CBM，FMJS,CNKIetc．Keyword included “GnRHa”，“chemotherapy”，“ovarian damage／ovarianfunction／premature ovarian failure”etc．We searched the literature includedstudies that reported an association between GnRHa and ovarian preservation inwomen receiving chemotherapy. Studies without a control group were excluded.Ovarian preservation was defined as the resumption of menstrual cycles and apremenopausal follicle-stimulating hormone (FSH) after chemotherapy.Fertility was determined by a woman’s ability to become pregnant.Software RevMan5.1.7WaS used to assess control trials．Results:seven papers were included．the total of cases were624．All of the studies hadhomogeneity(I2=0%，P>o．05)．so the study could be analyzed merged，which usedthe fixed—effect model．The result showed The use of GnRH agonists (GnRHa)during chemotherapy is protective of ovarian function.(P<0．01).Further evaluationsin adequately powered large RCTs are needed to confirm these findings．...