Synthesis, Insecticidal Activities And Stablity Of Neonicotinoid Analagues Containing Multi Aromatic Ring Structure

Neonicotinoids are a unique kind of insecticides with efficient biological activity in the field of pesticides. Our research group found a series of neonicotinoids compounds with conjugated nirto structure, which possess high insecticidal activity and poor stablity. In this paper, selective reduction is used to in add into the molecules of the lead compound in order to enhance the stablity without decrease of activity;45novel compounds have been synthesized via the method. All these compounds were comfirmed by NMR spectroscopy, HRMS, IR spectroscopy. The configuration was determined by crystal structure.Most of the synthesized compounds had good or excellent activities against Aphis medicaginis, Nilaparvata lugens and Meloidogyne incongnita; part of the target compounds had good activity against Plutella xylostella. One of the target compounds have quite excellent activity against both Alfalfa aphid and Plutella xylostella. At the same time, the LC50of another one against Aphis medicaginis is0.096mg/L。In addition, the stability test exhibited that the stability of novel analogues in water and under the mercury lamp has been improved significantly in comparison to the lead compound and imidacloprid.