A Study Of Body Composition And Flow-Mediated Endothelial Function In Pre-/Post-menopausal Women

Objective:Provide theoretical foundation for women to take precautions against obesity, osteoporosis and cardiovascular, and provide experimental support to exercise scientifically via revealing the relationship between body compositions and the change of FMD as independent predictors at an early stage.Methods:Subjects of156pre-/post-menopausal women living in Haitian District in Beijing provided the basic information and physical activity levels through questionnaires. Data (height, weight, chest waist and hip circumference) were gained from physical examination, body compositions were gained from dual-energy X-ray absorptiometry and FMD, base diameter, quiet blood flow velocity, and maximum speed were from high-resolution ultrasonography. Statistical inputs were performed by using Epidata Software and statistical analyses by SPSS16.0.Results:For women over forty, as the growth of the age:1) both body’ s and position’s bone mineral densities declined; decrease amplitude varied according to different parts; compared with the40-44group, the60years old and above group’s prominent changes took place at the spinal part (Δ=0.145g/cm2; p<0.01);2) both body’s bone mineral content and lean tissue showed an obvious downward trend, compared with the40-44group, the60years old and above group’s dropped respectively (Δ=374. lg, Δ=1600g; p<0.05);3) compared with the40-44group, the60years old and above group’s brachial artery FMD decreased with aging, decreased by0.74%on average, but no significant differences; base diameter, quiet blood flow velocity, and maximum speed of blood flow increased with aging;4) no correlation was demonstrated between FMD and body composition, but basic diameter and the biggest diameter had certain relevance with body composition, especially the whole body thin soft tissue content (Correlation were respectively r=-0.4and r=-0.39; p<0.01);5) High exercise and physical activity level could effectively affect the changes of body compositions and FMD. Especially on lean tissue, the average level increased4.1kg. Conclusion:1) Aging is important factor which causes the changes of both body composition and blood vessel function, and it also plays a pivotal role to the health of human body;2) The relationship between lean tissue and basic diameter indicates that lean tissue loss is more harmful to cardiovascular than adipose accumulation for women over40years;3) physical activity have a positive influence to vascular function, and this influence is likely to be with the changes of body composition.