Eczema Nano Cream Treatment Of Clinical Research Limitations Of Chronic Eczema

Objective:Eczema is a complex internal and external factors of a delayed-type hypersensitivity reactions, the cause is not very clear, the treatment of a variety of methods. Chinese medicine treatment of chronic eczema often used in diagnosis and treatment, medicine, outside the therapy, the effect is quite satisfactory. Which external treatment in traditional Chinese medicine plays a very important role in the treatment of chronic eczema in their formulations, the use of flexible, convenient and simple external treatment methods include drug wash, spray, paint, smoked, ironing, dressing, paste, acupuncture, etc. Traditional Chinese Medicine treatment of eczema often the use of a variety of therapies used in combination, but its safety and effectiveness is still a lack of clinical studies and scientific support. The purpose of this experiment is to observe the clinical efficacy of eczema nano treatment of focal chronic eczema cream (including Dan phenol, matrine, oxymatrine, berberine hydrochloride, borneol, menthol and other ingredients), for Traditional Chinese Medicine treatment of focal chronic eczema provide more treatment and to optimize external treatment program.Methods:This test uses double-blind, double-dummy observation, thepatients were randomly divided into the traditional Chinese medicine group (eczema nano cream group Jiayouzhuoer ointment analog agent group), plus the Western medicine positive control group (Zhuoer ointment eczema nano15cases in each of the three groups of the the ointment simulation agent group) and placebo in the control group (eczema nano cream analog agent Jiayouzhuoer ointment analog agent group), patients with traditional Chinese medicine group of30patients, western medicine group and the placebo group. Each patient from the rash area, the severity of the lesions and itching score, three weeks of continuous medication, decline in symptom score index SSRI calculated before and after treatment to determine the therapeutic efficacy and safety.Results:Off3cases not included in the statistics. Observed in patients with chronic eczema in57cases, including22males (38.6%), the average age was46.15±13.87years old,35females (61.4%), mean age49.62±13.69years old.(1) After treatment, Zhuoer group and the placebo group, the total effective rates were90.0%,85.7%and38.5%. The clinical efficacy of three groups by the chi-square test, X2=18.23, P=0<0.05, significant difference in efficacy among the three groups. Continue between the two groups, result:Chinese Medicines with Zhuoer group, X2=0.174, P=0.677>0.016; Chinese medicine group and the placebo group, X2=15.816, P=0<0.016; Zhuoer group wi th p lacebo group, X2=8.429, P=0.004<0.016. Known traditional Chinese medicine group and the placebo group, the Zhuoer and placebo groups in clinical efficacy were significant differences the Chinese Medicines Zhuoer group was not significantly different.(2) three sets of TCM syndromes by the chi-square test, X2=17.67, P=0.007<0.05, among the three groups were significantly different in efficacy. Continue between the two groups, result:Chinese Medicines with Zhuoer group, X2=0.670, P=0.413>0.016; Chinese medicine group and the placebo group, X2=15.301, P=0<0.016; Zhuoer group with placebo group, X2=6.454, P=0.011<0.016. Chinese medicine group and the placebo group, the Zhuoer and placebo groups in the improvement of TCM syndrome have significant differences, the Chinese Medicines Zhuoer group difference is not obvious.(3) The Board and the group Zhuoer the lesions scores increased after treatment decreased significantly (P<0.05) was statistically significant. Lesions points in the placebo group before and after treatment by paired t-test, P>0.05, no significant decline.(4) in each group after treatment, the degree of skin lesions itching points have different degrees of decline, P less than0.05, pruritus than before treatment differed significantly, have a significant effect on the itching.(5) The three groups of lesion area have varying degrees of reduced Chinese medicine treatment lesions score decreased significantly (P<0.05) was statistically significant. Lesions integral Zhuoer treatment and placebo groups did not decline significantly (P>0.05).Conclusion:in the consolidated efficacy, the the eczema nano-cream Zhuoer ointment efficacy is similar, and were significantly superior to placebo. Improve eczema nano cream of syndromes obvious to better than the ointment Zhuoer and placebo in TCM syndromes evaluation, waiting on a non-discriminatory, the ointment Zhuoer with placebo in improving the TCM. Points, itching integral lesions, the lesion area to improve the situation, the integral eczema nano-cream in the treatment were significantly lower than before treatment, efficacy significantly. The group Zhuoer improve skin lesions and relieve the itching efficacy obvious, but not obvious for the improvement of the lesion area.