| Overview:Adenomyosis (AM) refers to the endometrial invasion of the myometrium more than one high-power field. It used to be called internal endometriosis, but now is known as an independent disease. The pathological feature of AM is the invasion of endometrium and its glands in uterine muscle wall layer. It can be divided into diffused and localized type. The former means the ectopic endometrium invades throughout the uterine muscle wall layer, which is scattered in this layer. The degree and depth of immersion can be different. Referring to the latter, the ectopic endometrium only invades part of the muscle wall, like a tumour, no obvious boundaries with the surrounding normal tissues. The main clinical manifestations of the disease are secondary dysmenorrhea with progressive aggravation, overmuch menstrual blood volume, prolonged bleeding, and a minority of patients with infertility. The disease has a total case rate of5%～70%, and occurs more frequently in30～50year-old multiparas, about20%-50% with endometriosis, and about30% of patients with hystero myoma. The etiology is not clear so far. but the childbirth, abortion, IUD use group are vulnerable to this disease. At present western medicine treatment of the disease mainly depends on the hormone and operation, compared with western medicine, the conservative therapy of traditional Chinese medicine is more easily accepted by the patients, which is convenient and effective, with fewer side effects. There lore, the use of Chinese medicine treatment for AM (qi deficiency and blood stasis) has become one of the hottest topics of gynecological clinic.Objective:According to the Chinese and Western medicine theory, to observe the clinical effect of Fuke Xiaoliu pill, Danhuang Quyu capsule in the treatment of AM (qi deficiency and blood stasis), to explore its mechanism, and to provide a new train of thought and objective basis for clinical treatment.Methods:30cases of patients with AM (qi deficiency and blood stasis) were randomly divided into observation gump and control group. The observation group were treated by Fuke Xiaoliu pill (9g once,2times a day) and Danhuang Quyu capsule (1.6g each time,2times a day), the control group were treated with Dane Fukang Decocted Kxtract (every time15g, every day2times) and Bazhen granules (3.5g once, twice daily). The two groups were treated for3menstrual cycles continuously, and then observed for the clianges of clinical symptoms, signs, uterine volumes and serum CA125levels before and after the treatment.Results:There was no significant difference of the total effective rate in improving integrated sydrome between the two groups (P>0.05). There was a significant difference between two groups of curative effect of TCM syndrome (P<0.05). The total effective rate in the observation group was93.3%, while the control group was78.6%. There was a significant difference between two groups of TCM syndrome integral difference before and after treatment (P<0.05), and the difference of the observation group was larger than the control group. The dysmenorrhea integral differences of the two groups before and after treatment had a significant difference (P<0.05), and the difference of the observation group was larger than the control group. The menstrual integral differences of the two groups before and after the treatment had a significant difference (P<0.05), and the difference of the observation group was larger than the control group. The uterine volume differences of the two groups before and after treatment had a significant difference (P<0.05), and the difference of the observation group was larger than the control group. There was a significant difference between the two groups of serum CA125levels before and after treatment (P<0.05), and the difference of the observation group was larger than the control group. Patients of the two groups sufffered no adverse reactions during the treatment.Conclusion:This study emphasizes tonifying qi and nourishing blood, promoting blood circulation and removing blood stasis, using the same treatment to different diseases, and new use for old drugs. Fuke Xiaoliu pill and Danhuang Quyu capsule in the treatment of adenomyosis (qi deficiency and blood stasis) significantly improved the patient’s symptoms, signs, symptoms of dysmenorrhea, menstrual symptoms, and decreased uterine volumes by type-B ultrasound monitoring, and reduced the CA125levels. Apart from the same total effective rate in improving the integrated syndrome of the two groups, the observation medicines were superior to the control medicines on improving effects and degrees of the others. According to the conjecture, the two Chinese patent medicines achieved the purpose of treating the disease by improving the immune function and the state of blood rheology, analgesics and anti-inflammation, and had excellent clinical efficacy in the treatment of adenomyosis. |
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