Zhenwu Soup Flavor Treatment Of Kidney Disease Clinical Research

Objective:as changing of the people’s life style, the increasing pressure of life in China and speeding up of the aging, the incidence of kidney disease was gradually increasing. Nephrotic syndrome is incident bacause of Glomerular basement membrane permeability with glomerular filtration rate in a variety of diseases in the process, treatment is not easy, western medicine mainly using the sugar cortical hormone and cytotoxic drugs, but its side effects after treatment was big, and the effective not very good. Therefore, in traditional Chinese medicine for the treatment of reliable in effect of nephrotic syndrome formulas to have the important meaning. This paper discusses zhenwu tonga taste in the clinical curative effect of the treatment of kidney disease and mechanism, and hope for kidney disease’s treatment has the certain reference value.Methods:collected the100patients of nephrotic syndrome spleen and kidney with clinical observation to Taiwan taichung city hong spring hall TCM clinic outpatient clinic treatment,according to the sequence was divided into the treatment group and control group, each group of50cases, two groups of patients with age, sex, and the course, clinical manifestation, illness, biochemical index inspection general information to comparable, P>0.05. Patients in the department made by western medicine hospital routine therapy bbca method, the treatment group using zhenwu tonga on taste and treatment, the treatment after eight weeks to observe the supervision, compare clinical curative effect and the laboratory in the change of index before and after treatment, observe safety and efficacy sex. Safety evaluation standards are divided into:grade1:safety, without any adverse reactions. Level2: safe, and adverse reaction relatively minor, and don’t need to do anything, not interrupt taking. Level3:a security problem, a moderate adverse reactions, to treat, did not interrupt the drug. The levels is:adverse reactions are serious, because of adverse reactions to suspend the treatment. Clinical symptom scores refer to2002"issued by the Chinese herbal medicine new medicine clinical research guiding principle", will not, light, medium, heavy notes for0,1,2,3four ranks, tongue description will not be graded pulse. Will the outcome by nimodipine method expressed as a percentage. Syndromes curative effect evaluation of blood, effective and divided into invalid, disease curative effect evaluation into complete remission, basic ease, effective and invalid.Results:the total clinical curative effect:the total effective rate was arrived the86.0%, the traditional Chinese medicine treatment for symptomatic integral13.74+/-7.62, much lower than the20.41±10.41before treatment, P<0.05. After laboratory diagnosis, found this group of patients with24h urine protein, plasma albumin, uNAG, uRPB, SG after treatment were superior to the index before treatment, P<0.05. Kidney function:treatment group and blood urea nitrogen (BUN), serum creatinine (Scr), endogenous creatinine clearance (Ccr) were significantly improve, P<0.05. Before and after treatment group triglycerides (TG), total cholesterol (CHOL), high-density lipoprotein cholesterol (hdl-c), low density lipoprotein cholesterol (LDL)-c) improve significantly, P<0.05. Before and after treatment group is the systolic pressure, diastolic pressure were significantly improve, P<0.05. This group of patients did not appear during treatment of adverse events, no acne treatment group and centripetal obesity side effect, its side effects rate was6.0%, lower than in the incidence of literature research.Conclusion:zhenwu tong treatment nephrotic syndrome had good effective, to improve the clinical symptoms, protect the renal function, its mechanism may lie in lower urine protein, increase albumin, improve blood plasma, lower blood pressure, delaying and stop the progress of the disease, and worse, and application in found no obvious side effects, had high clinical value.