Change Chaotic And Dispelling Stasis Method Of Treatment Of Obstructive Sleep Apnea Hypopnea Syndrom (phlegm Turbidity Clip Stasis Type) Of Clinical Research

Objective:Compare the effect of resolving phlegm and removing statis treatments for phlegm and stasis of mild-to-moderate obstructive sleep apnea/hyponea syndromes with the treatment of theophylline, explore the herbs for OSAHS could be an effective treatment, and summary the pathogenesis of OSAHS.Method:1. Choose60patients,in accord with western medicine diagnosis criteria and classification standard of OSAHS, and accord with Chinese medicine syndrome diagnostic standard, and according to the random number list, the group of patients were randomly divided into trial group30cases and control group30cases.2. Treatment:give the patients of trial group formula of resolving phlegm and removing statis(banxial0g,chenpi10g,fuling20g,zhishi10g,shichangpul0g,yujin10g,cangzhu10g,zexiel5g,sanqifen3g,shenggancao6g,taking after decoction with water,a dose every day,each one time in the morning and evening), control group received theophylline (0.2g,bid),the observing time of two groups of treatment were21days. Before and after treatment,the TCM symptoms integral values. EpwortH sleepiness scale score. AHI value, minimum SaO2will be observed and compared.3. Statistical processing:the data processing is using the SAS8.2statistical software for statistical analysis, counting data with X2test; Measuring data with t test, paired t test; Grade material with X2CMH、rank sum test.lt was considered statistically significant when the value of P was less than0.05.Results:1.The gender, age. body mass index, the illness degree of two groups patients, by statistical analysis,no statistically significant difference (P>0.05),can be comparaed.2.OSAHS efficacy results:the trial group and the control group all have certain efficacy,and the two groups have no significant difference (P>0.05).3.TCM syndromes efficacy results:by X2CMH test,the total effective rate of two groups have significant difference(P<0.0001), the efficacy of the trial group is better than the control group. Both groups can improve patients’ snoring, suppress wake symptoms,but the two groups have no significant difference (P>0.05); The trial group can obviously improve lip nails dark purple, tired body weight, dazed head and headache symptoms,before and after the treatment,the control group have no significant difference in those symptoms, two groups have significant difference, the efficacy of the trial group is better than the control group.4. EpwortH sleepiness scale score results:after treatment,the EpwortH sleepiness scale score of two groups decreased,and have significant difference (P<0.05),but the two groups have no statistically significant difference (P>0.05)5. AHI value、minimum SaO2results:the two groups have no significant difference (P>0.05) in reducing AHI value and improving minimum SaO2.6. Adverse reaction monitoring:the two groups were nou found significant adverse reaction during treatment.Conclusion:The trial group can effectively improve related symptoms of OSAHS patients,especially in alleviating the symptoms of tired body weight, dazed head and headache;The control group can improve patients’ snoring, suppress wake symptoms,but can not alleviate the symptoms of lip nails dark purple, tired body weight, dazed head and headache;The two groups all can decrease the EpwortH sleepiness scale score,but can not reduce AHI value and improve minimum SaO2.