Cassia Twig Tuckahoe Pills The Governance Law Research And Clinical Observation For The Treatment Of 40 Cases Of Chloasma

Chloasma is a commonly seen capacitive skin disease, the pathogenesis of which is lowered body resistance and invasion by excessive pathogens.. The former is related to deficiency in the liver, spleen and kidney; while the latter to blood stasis and blood-heat. Recently, great progress has been made in the treatment of chloasma. However so many researches only focused on single case report and experience reviews, and there were few researches focusing on multiple case reports, which failed to sum up rules of treatment.. Guizhi, Fulin Pills (GFP) is the most famous formula used to promote blood circulation by removing blood stasis. There are few reports about the treatment of chloasma. The present study tries to focus on the clinical experience in the treatment of chloasma, while observe the effect of the GFP in the treatment of40cases of chloasma.Method:Based on the CNKI database, we accessed into the past16years (1995-2011) literature, collected clinical information about chloasma and the GFP. Statistical management was used to analyze the syndromes of chloasma, and the commonly used herbs and formulas for chloasma. We explored the feasibility of the GFP in the treatment of chloasma from a statistical point of view. By using statistical management, we analyzed the effect of the GFP in the treatment of40female patients with chloasma and. to some extent we have partly clarified the general rules in the treatment of chloasma with it.Result:This paper analyzed and compared the literature of the past16years from the CNKI database in the treatment of chloasma with herbal decoctions. Here is the summary:1.Differentiation of Syndromes:The main syndrome of chloasma was liver-qi stagnation,, accounting for27.95%; followed by spleen-deficiency, kidney-deficiency, respectively accounting for18.28%, and13.98%. Blood stasis was also the main reason of chloasma, accounting for23.66%; followed by blood-deficiency, accounting for11.83%; and blood-heat, accounting for2.69%. There was no record about blood-cold in literature. This was to confirme from one point that the main cause was stagnation and stasis..2. Formulas Used:: Stress was laid on activating blood circulation, and removing stagnated liver-qi., and,tonifying the kidney and spleen. The following is a list of the formulas used in order of frqquency:Taohong Siwu Decoction, Xuefu Zhuyu Decoction and the GFP.3. Herbs Prescribed in Order of Frequency:Danggui, Chaihu, Fulin, Honghua, Danpi, Chuangxiong, Taoren and Gancao, mainly for smooth blood and qi circulation, The most important method was to activate blood circulation and remove qi stagnation. Guizhi and Fulin played the main role in the treatment of chloasma, which provided an important basis for the possible role of the GFP in the treatment of chloasma.4. Pharmacology:The GFP inhibited tyrosinase activity, reduced the formation of melanin, regulated the body’s hormone level, improved blood rheology,and regulated the immune function. These provided a pharmacological basis for the GFP in the treatment of chloasma.To further validate the role of the GFP in the treatment of chloasma, we investigated its effect on chloasma in40female patients. The results are as follows:1. The incidence of chloasma was high between30-40years, and then40-50years.2. There were four kinds of skin lesions:butterfly type, central-face, jaw, and universal types. The butterfly type was mostly seen, then the central face type. These four types were more common between30-40years,3. Most chloasma patients suffered from bleeding, and varicose veins under the tongue.4. The effect of the GFP was excellent. The total effective rate of GFP was85%. Six patients failed to response, but they did not present significant bleeding manifestations. Patients between40-50years were easier to have symptoms caused by deficiency, and most of them had no response to the tretment.It indicated that the GFP was especially good to the syndrome of blood stasis.5. The butterfly type responsed mostly well to the GFP, and the total effective rate was92.86%. The universal type did not respond well, and the total effective rate was60%. Conclusion:High incidence of chloasma occurs in patients between30-40years, then between40-50years. The butterfly type is mostly seen and then the central face type. All of the four types are commonly seen in patients between30-40years.. The chief cause of the diseases is qi stagnation and blood stasis. In syndrome differentiation stress is laid on the liver, spleen and kidney. The blood type syndrome is caused by blood stasis and blood-deficiency. Most patients have bleeding manifestations,always accompanied by varicose veins under the tongue.. The herbal formulas aim at activating blood circulation. The majority of the prescribed medicinal herbs has already listed above. The GFP works to inhibit the tyrosinase activity and reduce the formation of melanin, regulate the hormone level, improve blood flow and blood rheology, and regulate the immune function. The effect of the GFP is excellent, having the total effective rate of85%. It is mostly indicated for the butterfly type and the blood stasis syndrome.