| Objective: This study is aimed to evaluate the differences and similarities of clinical manifestations and pathological features between male breast cancer(MBC)and female male breast(FBC),and to explore the prognostic factors and treatment protocols for them.Methods : Twenty-five patients who were diagnosed as male breast cancer from January 2006 to December 2014 in the First Affiliated Hospital of Bengbu Medical College were selected as the subjects.According to the principle of similar diagnosis and age of onset,the patients were matched according to the ratio of 1: 2,50 cases of female breast cancer patients were compared and analyzed.The clinical manifestations,pathologic features,lymph node metastasis and survival of male patients with breast cancer were analyzed retrospectively.The factors influencing the prognosis of male breast cancer,such as tumor size,lymph node metastasis,TNM stage,operation mode and postoperative adjuvant therapy,were analyzed by univariate analysis.Statistical analysis using SPSS21.0 version of the software.Use ?2test to compare the frequency between.Univariate analysis was performed by Kaplan-Meier method.Log-rank test was used to compare the curves between groups.P value <0.05 was statistically significant.Results:The age distribution of male breast cancer patients was between 43-78 years(61.32 ± 10.31),the median age was 58 years.Patients from the discovery of lumps to the treatment time span in 1-36 months(11.48 ± 10.64),the median time of 8 months.The age distribution of female breast cancer patients was between 43-79 years(61.12±10.14),the median age was 57 years.Patients from the discovery of lumps to the treatment time span in 1-7 months(2.68±1.62),the median time of 2 months.The5-year survival rate for male breast cancer is 40%.Univariate analysis showed that tumor size,lymph node status and TNM staging were associated with 5-year survival rates in patients with breast cancer(P <0.05);age of onset,location of tumor,tumor molecular typing,surgical procedure,postoperative adjuvant radiotherapy and chemotherapy There was no statistically significant difference between the 5-year survival rate and the male breast cancer patients(P> 0.05).Female 5-year survival rate for breast cancer patients was 62%.Tumor size,lymph node status,AJCC staging and assisted endocrine therapy(P <0.05)were associated with 5-year survival in women with breast cancer.Cox regression multivariate analysis showed that TNM staging was an independent factor affecting the 5-year survival rate of male and female breast cancer.Auxiliary endocrine therapy is an independent factor affecting the 5-year survival rate of female breast cancer.Conclusion: 1.Univariate analysis showed that the tumor size,lymph node status and AJCC staging affected the 5-year survival rate of male breast cancer.Multivariate analysis showed that tumor size and lymph node metastasis were independent factors affecting the 5-year survival rate of male breast cancer.2.There was no statistically significant difference in the 5-year survival rate between the surgical procedure and the male breast cancer patients,considering the statistical bias due to the small sample size taken for non-radical surgery.At the same time,patients taking non-radical surgery are often older,poor physical basis,the body's own disease will also affect the survival of patients.Univariate analysis showed no significant difference in tumor molecular typing and postoperative endocrine therapy in male breast cancer patients and 5-year survival rate in male patients with breast cancer.In this study,the positive rate of estrogen receptor in male breast cancer patients was higher than that in female breast cancer patients,but the rate of endocrine therapy in male patients with breast cancer was lower than that in female breast cancer patients.The endocrine effect of breast cancer has not been clearly confirmed.Therefore,in male breast cancer patients can not be considered estrogen / progesterone receptor positive represents a better prognosis,which may be related to the biological characteristics of male breast cancer.3.The 5-year survival rate of male breast cancer patients was significantly lower than the 5-year survival rate of female breast cancer in the case of matching time and age of onset.The prognosis is different from the biological characteristics of the tumor itself,but also with the treatment of breast cancer.At present,the treatment of male breast cancer basic reference to the treatment of breast cancer in women,the lack of male breast cancer for the characteristics and biological characteristics of the treatment.4.TNM staging is an independent factor affecting the 5-year survival rate of male and female breast cancer,so whether it is for breast cancer patients or women with breast cancer,should be in the clinical work of early diagnosis and early treatment. |
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