Clinical Analysis Of HeYingJieYu Decoction In The Treatment Of People With Post-stroke Depression

ObjectivePost-stroke depression (PSD) is a depressive state secondary to stroke. Its clinical manifestations similar to typical depression，thus low spirits，slow response and reduced verbal activity and motions，it is one of the most common complication ofstroke.During the study following Chen professor,I found use HeYingJieYu decoction to treat PSD was effective. So I conductedthis research，aimed to test and verify the HeYingJieYu decoction’s effect of the treatment of post-stroke depression patients and to investigate the cause and pathogeny of PSD and openup new ideas of the traditional Chinese medicine therapy.Methodswe totally bring76patients of WuHan First Hospital neurology in patient department during2011.6-2012.6into the survey.all patients were newly attacked with cerebral infarction（means get access to hospital after cerebral infarction attacked infourteen days），and all patients were confirmed by head CT/MRI.76patients were randomly divided into treatment group（40cases）and control group（36cases）. Both groups received the routineneurology Medical Treatment of cerebral infarction，and receive d the HeYingJieYu decoction therapy in addition.（Bai he30g，Bai shao15g，Zhi mu15g，Dan shen15g，Suan zao ren15g，and According to the principle of treatment based on syndrome differentiation，we add and subtract the decoction.patients with Qi depression，we add Chai hu15g，Chuan xiong15g，Xiang fu6g；with Phlegm，we add Dan nan xing15g，Zhu ru15g；Ban xia15g；with Blood stasis，we add Tao ren15g，Hong hua10g，Dang gui10g；with Yin deficiency，we add Huai niu xi30g，Tian dong15g，Xuan shen15g；with Yin and Yang deficiency，we add Rou gui15g，Zhi fu zi6g，Shu di30g，we made it water decoction，taking200ml at one time，two times a day.Control group treated with sertraline100mg/d. we statistics patients’ HAMD scores，NIHSS scores，ADL scores after they admitted to hospital and at the2,6,10weeks after therapy. Evaluate the Effect of improvement ofthe symptoms of depression and Nerve function defect. Recordsof adverse reactions in the treatment process.we conduct Bloodbiochemical examination and ECG after patients admitted to hospital and at the10weeks after therapy for safety assessment。ResultsAnalysis the statistical data we got，We did not found obvious different in ages, level of education,sex, degree of nerve function defect between two group. We use HAMD score decrement rate to Evaluate the efficacy of HeYingJieYu decoction（we set three levels：Significant effect，decrement rate>60%；normaleffect，decrement rate between30%-60%；invalid，decrement rate<30%）.we observed effective rate of treatment group was88%,compared with84%of control group,the result did not show significant different. While in the aspect of improvement of nerve f unction defection,treatment group show advantage than controlgroup. There is statistical significance Differences between the treatment group and the control group which measured by NIHSS scale and BI scale,suggested the HeYingJieYu decoction can give consideration to both stroke and depression.and one more exciting results was there was no Adverse reactions happened during the threpy，thus proved its safety in used in clinical.ConclusionsTreat post-stroke depression by the HeYingJieYu decoction，for it gives consideration to both stroke and depression，Not only can it significantly improve patients with depressive symptoms，But also can promote nerve function defect recovery.and the most important，there was no adverse reactions.