| Objective:To understand the current situation of the quality of life in ovarian cancer patients, investigate the symptom clusters, as well as the impact of the influencing factors on their quality of life. Evidence was presented for healthcare provider to manage symptoms effectively, alleviate discomfort and improve the patients’quality of life.Method:Patients from a comprehensive hospital in Jinan City were recruited randomly. A total of130patients with advanced stage ovarian cancer confirmed by postoperative pathologic examination were recruited. We used questionnaire packages including social demography, MDAS, PCL-CFACT-O. The date were processed by SPSS17.0for analysis. Statistical terms such as frequency, rate, mean, and standard deviation were used to describe social demography date, symptom total scores, scores of each dimension of patients" PCL-C and FACT-O. Analysis of variance was used to compile statistics of the difference level of Patients’quality of life among groups. The principal component analysis was used to describe the symptom clusters. The Pearson correlation analysis was used to analyze relationship among quality of life, symptom clusters and Post-traumatic stress disorder. Quality of life as the dependent variable, Relevant factors as independent variables, multiple stepwise regression analysis was used to discuss. Result:1.The mean score of130patients’symptoms were37.82±6.51, the top five were fatigue, lack of appetite, disturbed sleep, pain, distress(emotional).These symptoms had an obvious impact on mood. Four factors were obtained including affective symptom, somatic symptom, side effects of treatment and gastrointestinal symptoms after factor analysis of13items from the MDASI, which the highest score is somatic symptom.2.The mean score of Post-traumatic stress disorder were35.27±4.77, PTSD-positive patients were28(21.54%).The score of Post-traumatic stress disorder in PWB, SWB, FWB and FACT-O had significant difference, and it was significant correlated with affective symptom.3.The mean score of quality of life was96.78±5.13.The social demography had no statistically differences with quality of life, whereas disease stage and ECOG had significant differences. Affective symptom, somatic symptom, gastrointestinal symptoms had negatively correlated with PWB,EWB,FWB,OCS and FACT-O, whereas side effects of treatment had negatively correlated with PWB,SWB,FWB,OCS and FACT-O. Post-traumatic stress disorder had negatively correlated with PWB, SWB, FWB and FACT-O.4.The multiple linear regression analysis results showed that the main factors influencing the quality of life were affective symptom, post-traumatic stress disorder and ECOG, which were used to explain66.0%of variance in the quality of life. The other symptom clusters and relevant factors had no significant influence on the quality of life.Conclusion:1.Total level of quality of life and the scores of each dimension of ovarian cancer patients were in middle level. But sexual life dysfunction was in lower level than other items, which indicated that the healthcare providers should strengthen the communication with patients about this, tell the importance of the sexual life, and give them effective mental guidance and treatment.2.In this study, somatic symptoms are the most puzzles patients with the question among symptom clusters, so the medical staff fully understand the patient’s symptoms, and according to the specific circumstances of the patient to formulate targeted interventions to improve their quality of life.3.In this group of patients with post-traumatic stress disorder is more serious than the similar research. The higher level of affective symptoms, the more obvious of post-traumatic stress disorder.4.Affective symptoms, post-traumatic stress disorder and ECOG had a significant impact on their quality of life, which showed that we would adopt the effective interventions, give the well timed mental state guides and support therapy, and improve their functional states and quality of life. |
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