Comparative Study Of The Effect Of Xuebijing Injection And Ulinastatin On Patients With Acute Exacerbation Of Chronic Obstructive Pulmonary Disease And Systemic Inflammatory Response Syndrome

Objective:Comparative the effect of Xuebijing injection and ulinastatin on patients with acute exacerbation of chronic obstructive pulmonary disease and Systemic Inflammatory Response Syndrome.Methods:According to inclusion criterions,82patients with AECOPD and SIRS from October2011to February2013in Fuzhou General Hospital of Nanjing Military Region were divided randomly into three groups:control group(27cases),Xuebijing group(28cases) and ulinastatin group(27cases).All patients were given conventional therapy of western medicine,such as controlled oxygen therapy, anti-infection, spasmolysis, asthma, phlegm and other conventional treatment.Xuebijing group was treated with Xuebijing Injection on the basis of conventional treatment.Ulinastatin group was treated ulinastatin on the basis of conventional treatment. Peripheral white blood cell count (WBC), C-reactive protein (CRP), calcitonin (PCT), platelet count (PLT), fibrinogen (Fib), D-dimer and flow cytometer-CD4, flow cytometer-CD8, flow cytometer-CD4/CD8were assaied before and on the4th,8th day after treatment as same as occurrence of MODS.At last,all datas were analyzed by SPSS16.0for windows.Results:1.There were insignificant difference of general material、WBC、CRP、PCT、PLT、 Fib、D-dimer、flow cytometer-CD1、flow cytometer-CD8and flow cytometer-CD4/CD8between each group before any treatment.2.On the4th day, the level of Xuebijing group’s PCT was lower than the other groups(P<0.05).On the8th day,the level of WBC、CRP、PCT、PLT、Fib and D-dimmer in each group were improved than that before treatment.And Xuebijing group’s PLT increased, Fib and D-dimer decreased significantly than the other two groups (P<0.05).No statistical significance was observed before and after treatment on CD4, CD8, CD4/CD8(P>0.05).3. Either the4th day or the8th day, the overall result of Xuebijing group were significantly higher than the control group. On the4th day, the overall result of Xuebijing group were significantly higher than Ulinastatin group.But there was no statistically significant difference between the two groups on the8th day(P>0.05).Conclusions:1.Xuebijing injection and ulinastatin can effectively improve the clinical symptoms of patients with AECOPD and SIRS, reducing inflammation.Xuebijing injection’s curative effect was more significant than ulinastatin,due to it’s therapeutic efficacy on bacterial.2.Xuebijing injection and ulinastatin can improve coagulant function of patients with AECOPD and SIRS.The improvement of coagulant function of Xuebijing injection was obviously better than that of ulinastatin.3.Whether Xuebijing injection and ulinastatin can enhance the cellular immune function in patients with AECOPD and SIRS or not needs further study.