The Effects Of Pretreatment Acupoint Injection Of Xiangdan Parenteral Solution At Neiguan(PC6) On ICAM-1and NF-κB In Acute Myocardial Ischemia Rats

The objective:To study the influence of pre-injected XiangDan parenteral Solution into PC6on endothelial injury and endothelial secretion by testing the adhesion molecule-1(ICAM-1) and nuclear transcription factors influence of NF-κB in rats model. Explore PC6point injection of XingDan injection myocardial ischemia and related factors of inflammatory benign adjustment, thus clear point injection of myocardial pretreatment of protection.Method:These experiments with SD rats subjects, cause myocardial ischemia preconditioning before give point injection14days, then through the abdominal cavity subcutaneous injection isoproterenol (isoproterenol, ISO) induce myocardial ischemia model, myocardial for pathological morphology observation and immunohistochemical detection ICAM-1and NF-κB changes.Result:(1) After acute myocardial ischemia in rats, the myocardial ischemia has a typical of the pathological morphology change of oxygen. Shut in the hole injection XingDan injection group (hereinafter referred to as the needle medicine group) has significantly reduce rat for acute myocardial ischemia cause myocardial impairment, reduce lesions degree and range, and add the repair the damaged area of books. Drug control group and point injection group to the improving function of myocardial injury than rev. Needle medicine group.(2) Rats in coronary artery blood wall after myocardial ischemia, thickening lumen narrowed. Needle medicine group, the drug control, point injection group can reduce hemal wall are the thickening degree, but each comparison between no statistical significance.(3) After myocardial ischemia in rats myocardial ICAM-1content increased, needle medicine group, the drug control group and point injection group after pretreatment are can reduced.Conclusions:1, inside pass point injection sweet Dan injection of acute myocardial ischemia preconditioning rat myocardial protective.2, inside pass point injection sweet Dan injection can reduce the blood vessel wall pretreatment thickening degree, reduce coronary local ICAM-1, NF-κB expression; By reducing the myocardial inflammation factor expression, to reduce after myocardial ischemia the purpose of tissue damage.