Study On The Relationship Between Traditional Chinese Medical Syndromes And Response To Oxymatrine Combined Ifn-αin HBeAg-positive Chronic Hepatitis B Patients

Objectives:Study on the relationship of the effect of Oxymatrine combined IFN-α between Hepatic Stagnation and Spleen Deficiency Type&Damp-Heat Accumulated Type in HBeAg-positive chronic hepatitis B(CHB) patients, in order to help clinical doctors to choose a more efficient IFN-α under the guidance from traditional Chinese medicine (TCM) treatment based on syndrome differentiation in HBeAg-positive chronic hepatitis B patients.Methods:Select60cases for each Hepatic Stagnation and Spleen Deficiency Type&Damp-Heat Accumulated Type of HBeAg-positive chronic hepatitis B patients. Each group divided into2groups, each group30cases. Group A for Hepatic Stagnation and Spleen Deficiency Type treated with IFN-α. Group B for Damp-Heat Accumulated Type treated with IFN-α. Group C for Hepatic Stagnation and Spleen Deficiency Type treated by Oxymatrine combined IFN-α. Group D for Damp-Heat Accumulated Type treated by Oxymatrine combined IFN-α. Detect the serological conversion rate and the dynamic change of HBeAg, the conversion rate of lower detected level and the dynamic change of HBV-DNA, the normal rate of ALT as well as side effects, with whom have treated for half a year and follow-up for half a year after the treatment.Results:Follow-up for half a year after the treatments, the serological conversion rate of HBeAg were17.86%、18.52%、41.38%and17.86%,the conversion rate of lower detected level HBV-DNA were17.86%、22.22%、48.28%and21.43%, respectively from groups A to D. The normal rate of ALT were42.86%、40.74%、51.72%and50.00%. On the serological conversion rate of HBeAg and the conversion rate of lower detected level of HBV-DNA aspect, the effect of group C, the Hepatic Stagnation and Spleen Deficiency Type treated by Oxymatrine combined IFN-α is obviously better than the other three groups (P<0.05). The normal rate of ALT and side effects show no significant differences among these four groups(P>0.05).Conclusion:1st. The curative effect treated by Oxymatrine combined IFN-α is better than treated by independent use of IFN-α;2nd. It is more superior for Hepatic Stagnation and Spleen Deficiency Type patients treated by Oxymatrine combined IFN-α.3rd.Independent use of IFN-α or Oxymatrine combined IFN-α shows no differences on the normal rate of ALT between Hepatic Stagnation and Spleen Deficiency Type&Damp-Heat Accumulated Type in HBeAg-positive chronic hepatitis B patients.