Association Of OPG System And Carotid Atherosclerosis Syndrome Of Blood Stasis

Objective:Investigate correlation between the OPG system and carotid atherosclerosis Syndrome of blood stasis.Methods:Select carotid atherosclerosis(CAS) Syndrome of blood stasis patients(102cases), the non-blood stasis syndrome of CAS(58cases) and normal control group(40cases), detected by enzyme-linked immunosorbent assay (ELISA) serum OPG and nuclear factor and receptor activator of factor ligand (souble-RANKL, sRANKL) concentration,according to the CAS degree of hardening and CAS stasis degree of statistical analysis to explore the significance of CAS Syndrome of blood stasis.Result:1. There was no significant difference (P>0.05) in triglycerides (TG),high density lipoprotein(HDL-C),low density lipoprotein(LDL-C), C-reactive protein(CRP) by comparison of risk factors among three groups (CAS blood stasis, CAS non-blood stasis syndrome and control group). Smoking rates, the incidence of hypertension, the incidence of diabetes and the coronary heart disease rates were significantly different (P<0.05) among the three groups, CAS blood stasis group and CAS non-blood stasis syndrome group were significantly higher (P<0.05), but there was no statistically significant difference (P>0.05) in CAS blood stasis syndrome group and CAS non-blood stasis syndrome group. There was a significant difference (P<0.05) in BMI among three groups, CAS blood stasis syndrome group was significantly higher (P<0.05) than control group, there was not statistically difference (P>0.05) between the comparison of CAS blood stasis syndrome group and control group with the CAS non-blood stasis syndrome group. Cholesterol (TC) was significantly different (P<0.05) among the three groups, CAS blood stasis syndrome group was significantly higher (P<0.05) than control group, there was not statistically difference (P>0.05) between the comparison of CAS blood stasis syndrome group and control group with the CAS non-blood stasis syndrome group.2.There was difference (P<0.01) in serum of OPG, sRANKL levels among CAS blood stasis, the CAS non-blood stasis syndrome and control group respectively, in which there were both significant difference(P<0.05) between the comparison of CAS blood stasis group and control group with CAS non-blood stasis syndrome group and control group, as of serum OPG levels, CAS blood stasis syndrome group was significantly higher than the CAS non-blood stasis syndrome group (P<0.05), as of serum sRANKL level, CAS blood stasis syndrome group and CAS non-blood stasis syndrome group showed no statistically difference (P>0.05).3. CAS blood stasis group is divided into grade1(48cases), grade2(33cases), grade3(21cases) as of hardening. Among the three groups, serum OPG levels were significantly different (P<0.01), sRANKL level was no significant difference (P>0.05); grade3of serum OPG levels CAS blood stasis sclerosis was significantly higher than gradel and grade2(P <0.05), grade2was significantly higher than grade1(P<0.05).4. CAS blood stasis group according to the degree of stasis is divided into mild (40cases), moderate (35cases), severe (27cases) group. Among the three groups, there was a significant difference (P<0.01) in serum of OPG, sRANKL level; serum OPG levels CAS blood stasis severe group was significantly higher than the moderate group and the mild group (P<0.01), the moderate group was significantly higher than the light severe group (P<0.01); serum sRANKL level in CAS blood stasis re-severe group and the mild group was significantly higher than the mild group (P<0.01), while there was no statistically significant difference (P>0.05) between the moderate group and severe group.5. Score of CAS Syndrome of blood stasis extent was positively correlated with serum OPG level (r=0.571, P<0.01), also with serum sRANKL level as well(r=0.160,.P>0.05).Conclusion:1.By means of comparison of the CAS-related risk factors (such as BMI,the TC, smoking rates, incidence of hypertension, incidence of diabetes, coronary heart disease rates) in CAS blood stasis, CAS non-blood stasis syndrome and control groups, CAS blood stasis syndrome group was significantly higher than the other groups.2. Serum of OPG, sRANKL levels are related with the incidence of CAS, in particular, significant changes in the CAS blood stasis.3. Serum OPG levels in CAS patients with blood stasis syndrome group is higher than that n the non-blood stasis syndrome group.4. Serum OPG levels is related with CAS degree of hardening, and with the severity of hardening increased.5. Serum of OPG, sRANKL level and CAS stasis degree is of a positively correlated, with which the severity of blood stasis, serum OPG levels increased more significantly.