Analysis Of Relationship Between Traditional Chinese Medicine Stasis-syndrome And Serum Homocysteine In Young Adult And Elderly Cerebral Infarction Patients

Objective:Analysis of relationship among erebral infarction risk factors, Condition and the level of serum homocysteine in young adult and elderly cerebral infarction patients; Analysis of relationship between traditional chinese medicine stasis syndrome and the level of serum homocysteine in young adult and elderly cerebral infarction patients, for Combination of Chinese traditional and Western Medicine treatment of acute cerebral infarction to provide a new theoretical approach and clinical guidance.Methods:Selection for acute atherosclerotic cerebral infarction with120cases (course within2days),young adult patients were divided into group A with60cases,32males,28females, age(45.07±7.32); elderly patients were divided into group B with60cases,31males,29females, age (69.63±6.20);Selection of healthy young adult control group C with30cases,16males,14females,age(46.77±8.34);Healthy elderly control group D with30cases,15males,15females, age(67.37±5.10).The group A and B according to the Chinese medicine syndrome standards were divided into the stasis syndrome group and non stasis-syndrome group. Over the same period of cerebral infarction patients admitted to hospital within2days and young adult, elderly health examination were collected fasting venous blood4ml sent to hospital inspection center, within1hours to centrifugal for hospital central laboratory,-70degrees C refrigerator, centralized quarantine the level of Hey, FA and VitB12.At the same time collecting venous blood6ml is sent to the hospital inspection center detection of lipid, glucose, such as liver and kidney function index. And according to the patients’ clinical symptoms, signs and stasis syndrome integral, the United States of America NIH Stroke Scale (NIHSS) score. Results using SPSS18.0software package was used for statistical analysis.Results:1. Subjects were clinically common data comparison:The difference of Each group had not statistically significant in gender(P>0.05); The difference of group A and C, group B and D had not statistically significant in age(P>0.05);The level of SBP, GLU, TG, CHOL, LDLC with group B was higher compared with group A,But the difference was not statistically significant (P>0.05),The difference of group C and D were not statistically significant (P>0.05).2. The level of the Hey and SBP, DBP, GLU, TG, CHOL, LDLC with Groups correlation analysis:The level of the Hey and GLU,DBP,TG, CHOL, LDLC with group A, B, C, D had no significant correlation (P>0.05);The level the Hey and SBP with group A, B were positively correlated, and there was statistical significance (group A, r=0.24, P=0.04; group B, r=0.29, P=0.01);The Hey of group C, D and SBP had no significant correlation (P>0.05).3. The level of the Hey, FA,VitB12and the detection rate of HHcy, the score of NIHSS for comparison with Each group:The level of the Hey of both group A,B were significantly higher than group C, D, the difference was statistically significant (P<0.01);The level of the FA of both group A,B were significantly lower than group C, D, the difference was statistically significant (P<0.01);The level of the Hey, FA of both group A with B,group C with D had no significant difference (P>0.05);The detection rate of HHcy of both group A, B were significantly higher than group C, D, the difference was statistically significant (P<0.01),The detection rate of HHcy of group A was significantly higher than group B, the difference was statistically significant (P<0.01),The positive rate of HHcy of group C with group D had no significant difference (P>0.05); The level of the VitB12with among group A, B, C and D had no significant difference (P>0.05);The score of NIHSS with group A was significantly higher than group B, the difference was statistically significant (P<0.05),4. The level of the hcy and the score of NIHSS correlation analysis with both groupA,B:The level of the Hey and the score of NIHSS with both group A,B have positive correlation, and the linear relationship (group A, r=0.77, P<0.01; group B, r=0.64, P<0.01).5. The level of the Hey and FA, VitB12correlation analysis with each groups:There was a negative correlation between the level of the Hey and FA with among group A, B,and C(P<0.05),Correlation of group D had no statistical significance (P>0.05);The level of the Hey and VitB12correlation with among group A,B,C and D had no statistical significance (P>0.05).6. The level of the Hey, score of stasis syndrome and detection rate of both stasis syndrome and non-stasis syndrome with group A,B comparison:The detection rate of stasis syndrome of group A was significantly higher than group B,but the difference no statistical significance (P>0.05).The level of the Hey of both group stasis syndrome with group A,B were significantly higher than non-stasis syndrome with group A,B, the difference was statistically significant (P<0.01),The level of the Hcy of both group stasis syndrome with group A and B,group non stasis syndrome with group A and B had no significant difference (P>0.05);The score of stasis syndrome of group A higher than stasis syndrome of group,but the difference was not statistically significant (P>0.05).7. The score of stasis syndrome and the level of Hcy linear correlation analysis with both group A,B:The score of stasis syndrome and the level of Hcy have positive correlation with group A, and show a linear correlation (r=0.89, P<0.01); The score of stasis syndrome and the level of Hcy have positive correlation with group B, and show a linear correlation (r=0.85, P<0.01).8. The score of stasis syndrome and NIHSS linear correlation analysis of both group A,B:The score of stasis syndrome and NIHSS have positive correlation of group A, and show a linear correlation (r=0.78, P<0.01);The score of stasis syndrome and NIHSS have positive correlation of group B, and show a linear correlation (r=0.73,P<0.01).Conclusions:1.The level of the Hcy of both group young adult patients,Older patients were significantly higher than group health examination,The HHcy is a factor of independent risk with atherosclerotic cerebral infarction;the HHcy leading to atherogenic mechanisms may be have synergistic or interaction mechanism with SBP.2.The Incidence of HHcy was closely related to age, the young adult patients was higher than Older patients with the Incidence "rate of HHcy.3.The Older patients was higher than young adult patients with the score of NIHSS,Cerebral infarction both young adult and older with time slots corresponding to the level of the Hcy was positively correlated with the score of NIHSS, May reflect impaired neurological function of stroke severity.4.The level of the FA both young adult patients and Older patients were not obvious difference,There was a negative correlation between the level of the Hcy and FA with adult patients and Older patients, was caused by Hcy in atherosclerotic cerebral infarction in the important mechanism.5.The detection rate of stasis syndrome, the level of Hcy,the score of stasis syndrome both young adult patients and older patients were not obvious difference, the score of stasis syndrome was closely correlated with the level of the Hcy with adult patients and Older patients,The HHcy and stasis syndrome were had a simila pathogenic mechanism, the level of the Hcy can be used as a stasis syndrome of stroke Syndrome type of one objective index.6.The time slots corresponding to the score of stasis syndrome was linear correlated with the score of NIHSS with adult patients and older patients, the score of stasis syndrome is considered to be a measure of stroke patients degree of neural function defect indicator.