Clinical Efficacy Of Folic Acid Combined With Vitamin B12 In Young And Middle-aged Male Patients With Cerebral Infarction To Hyperhomocysteinemia

Objective:To explore the treatment of folic acid and vitamin B₁₂ of young and middle-aged male cerebral infarction with hyperhomocysteinemia（HHcy）disease in patients with clinical curative effect and secondary prevention role.Methods : 100 patients with hyperhomocysteinemia and first attack of cerebral infarction patients were randomly divided into two groups,50 cases into A group,another 50 cases into group B.Our team according to the guidelines of diagnosis and treatment of ischemic stroke treated two groups,group A was treated another with folic acid and vitamin B₁₂.Respectively in 3 months,12 months to observe NIHSS scores,Barthel index（BI）pionts,plasma homocysteine levels and cerebral infarction recurrence rates by year’s end in two groups.Results:（1）Two groups before and after treatment plasma Hcy levels comparison: the two groups before treatment plasma Hcy levels in group A was（22.05 ±4.44）umol/L,group B was（21.27 ±3.79）umol/L,there was no significant difference（P > 0.05）,A group of 3 months after treatment,plasma Hcy level was（13.57 ± 2.57）umol/L,after 12 months plasma Hcy level was（10.61 ±3.13）umol/L,B group of 3 months after treatment,plasma Hcy levels was（19.62 + 3.19）umol/L,after 12 months plasma Hcy levels was（18.31±4.45）umol/L,compared the two groups,group A plasma Hcy concentration significantly reduced,was lower than that in group B（P < 0.05）;（2）Two groups before and after treatment NIHSS scores comparison: two groups of patients on admission NIHHS scores,group A（9.86±4.59）pionts and group B（9.53±4.47）pionts,the two groups before treatment NIHSS scores had no significant difference（P > 0.05）,A group of patients with folic acid and vitamin B₁₂ treatment after 3 months,patients with NIHSS scores was（4.55±2.33）points,after 12 months treatment was（3.02±1.73）points;Group B after treatment for 3 months and 12 months,NIHSS scores were respectively（5.91 ±2.93）and（4.44±2.27）points;NIHSS scores after treatment in both groups all have different degrees of lower（the average P < 0.05）,but NIHSS scores of A group was significantly lower than that of group B（the average P < 0.05）;（3）Compared two groups before and after treatment in daily life ability: Two groups of patients before treatment,BI scores in more than 60 points were 7 cases of group A and group B 8 cases,there was no statistically significant difference（P > 0.05）;3 months after treatment group A BI scores had 32 cases in more than 60 points,B group 26 cases,BI scores of two groups 3 months before there was no significant difference（P > 0.05）,after 12 months,BI score of group A has 39 cases in more than 60 points,and B group has 30 cases.BI scores in more than 60 cases of group A than group B（P < 0.05）;（4）In the two groups before and after treatment m RS scores omparison: Before treatment group A m RS scores 0 to 2 points had 3 cases,3 5 points had 41 cases,and that in group B was respectively 2 cases and 43 cases,by the chi-square test,the two gropes has no obvious difference（P > 0.05）;3 months after treatment,group A had 26 cases of m RS scores 0 to 2 points,18 cases of 3 to 5 points,B group of 17 cases of 0 to 2 points,28 cases of 3 to 5 points,by the chi-square test,the two groups had significant difference（P < 0.05）;12 months after treatment group A of m RS score 0 2 points had 33 cases,11 cases of 3 5 points,and B group were respectively 23 cases and 11 cases,neural functional recovery of group A is better than that of group B,the two groups have significant difference（P < 0.05）;（P < 0.05）;（5）A group of 3 cases of recurrence,the recurrence rate was 6.8%,3 cases of group B recurrence,the recurrence rate was 22.2%（P < 0.05）.Group A in the control process of homocysteine no severe adverse reaction occurred.Conclusion:The use of folic acid and vitamin B₁₂ treatment of middle-aged and young men with high homocysteine.Patients with cerebral infarction by reducing plasma Hcy levels,can improve the prognosis of cerebral infarction of young and middle-aged male with hyperhomocysteine,and effectively reduce the cerebral infarction recurrence within 1 year.